2026년 35주차

apixaban우선순위 중간ICSR 검토체계적 문헌고찰리뷰

Apixaban Versus Low-Molecular-Weight Heparin in Cancer-Associated Thrombosis: An Indication-Stratified Systematic Review and Meta-Analysis of Treatment and Postoperative Prophylaxis.

Apixaban is increasingly used as an alternative to low-molecular-weight heparin (LMWH) in patients with cancer, but evidence spans distinct clinical settings, including treatment of established cancer-associated thrombosis/venous thromboembolism (CAT/VTE) and postoperative thromboprophylaxis. We performed an indication-stratified systematic review and met…

PMID 42622790 · Cardiovascular drugs and therapy

PMID 42610175 · Iranian journal of nursing and midwifery research

apixaban우선순위 중간ICSR 검토기타

Apixaban vs Enoxaparin for Preventing Postoperative Thromboembolic events in Women Undergoing Surgery for Gynecologic Cancers: A Randomized Clinical Trial Study.

Venous thromboembolism (VTE), encompassing deep venous thrombosis and pulmonary embolism, presents a significant clinical risk for women undergoing surgical intervention for gynecologic malignancies. Enhanced prophylactic strategies are vital to mitigating these complications. This study evaluates the efficacy and safety of oral apixaban compared to subcu…

PMID 42615067 · Archivos peruanos de cardiologia y cirugia cardiovascular

Intracavitary thrombus in the left ventricle and high-risk pulmonary embolism. A case report.

Massive pulmonary embolism (PE) is a life-threatening condition typically requiring systemic thrombolysis. The presence of a left ventricular (LV) thrombus represents a relative contraindication due to the high risk of systemic embolization, requiring individualized management. We present a 73-year-old woman with a history of non-Hodgkin lymphoma in remis…

Left Ventricular Thrombus Despite Prescribed Direct Oral Anticoagulant Therapy in Chronic Heart Failure With Reduced Ejection Fraction: A Case Report and Review of Risk Stratification.

Left ventricular thrombus (LVT) remains a clinically important complication associated with increased risks of systemic thromboembolism, ischemic stroke, and adverse cardiovascular outcomes. The optimal duration of anticoagulation treatment remains difficult to establish, and it should be individualized depending on patient characteristics. We present the…

PMID 42633126 · Cureus

PMID 42622585 · JACC. Case reports

Staged Antithrombotic Reinitiation After STEMI Complicated by LV Thrombus and Intracerebral Hemorrhage.

Left ventricular thrombus after anterior ST-segment elevation myocardial infarction requires anticoagulation, and recent stenting requires dual antiplatelet therapy, but no guideline addresses antithrombotic sequencing when intracerebral hemorrhage complicates both. A 63-year-old woman developed an apical left ventricular thrombus after left anterior desc…

PMID 42609934 · Acta medica Lituanica

Stroke and Recurrent Thrombosis of the Coronary Arteries Probably due to Patent Foramen Ovale and Antebrachial Vein Thrombosis in Patient with STEMI - Case Report.

A 74-year-old woman with a history of cryptogenic stroke in 2010 (during hospitalization at the neurological department, possible reasons of stroke were excluded at that time), with less than one year history of paroxysmal atrial fibrillation (AF), which was being treated with apixaban, and also exhibiting hypertension, diabetes type II, hypothyreotocsico…

dabigatran우선순위 중간ICSR 검토기타

Safety and effectiveness of dabigatran vs rivaroxaban in nonvalvular atrial fibrillation patients at nutritional risk.

Malnutrition is a prevalent comorbidity in nonvalvular atrial fibrillation (NVAF), yet comparative evidence on oral anticoagulants in this vulnerable population is scarce. We aimed to compare the safety and effectiveness of dabigatran with those of rivaroxaban in NVAF patients at nutritional risk. This new-user, active-comparator cohort study utilized dat…

PMID 42620299 · Research and practice in thrombosis and haemostasis

dabigatran우선순위 낮음근거 검토기타

Safety in the Age of Artificial Intelligence: Evaluating Large Language Model Adherence to Antithrombotic Medication and Regional Anesthesia Guidelines.

The release of the 2025 American Society of Regional Anesthesia (ASRA) 5th edition guidelines for regional and neuraxial anesthesia procedures for patients receiving antithrombotic medications introduced complex, patient-specific hold times and resumption protocols. As clinicians increasingly utilize large language models (LLMs) as clinical decision suppo…

PMID 42614371 · Cureus

PMID 42630602 · Frontiers in cardiovascular medicine

dabigatran우선순위 낮음근거 검토리뷰

The use of direct oral anticoagulants in children with congenital and acquired heart disease.

Direct oral anticoagulants (DOACs), including the direct thrombin inhibitor, dabigatran, and factor Xa inhibitors (rivaroxaban, apixaban, and edoxaban), represent a significant advancement in pediatric anticoagulation therapy. Following U.S. FDA approvals for dabigatran and rivaroxaban in 2021 and apixaban in 2025, DOACs are now available for venous throm…

PMID 42631158 · American journal of translational research

edoxaban우선순위 중간ICSR 검토기타

Edoxaban plus aspirin de-escalation strategy versus continuous dual antithrombotic therapy in the perioperative period for patients with atrial fibrillation undergoing carotid artery stenting: a retrospective cohort study.

To compare the safety and efficacy of an edoxaban-based, time-limited dual antithrombotic therapy followed by a de-escalation strategy versus a continuous dual antithrombotic strategy in patients with atrial fibrillation (AF) undergoing carotid artery stenting (CAS). A total of 120 patients with CAS and AF who underwent surgery at Guizhou Panjiang Investm…

rivaroxaban우선순위 중간ICSR 검토증례보고

A Rare Presentation of Behçet's Disease: Coexistence of Intracardiac Thrombi, Coronary Artery Disease, and Pulmonary Thromboembolism.

Behçet's disease (BD) is a rare systemic vasculitis. While pulmonary involvement occurs, severe intracardiac manifestations are exceptional. We report a 44-year-old male presenting with dyspnea and hemoptysis. Multimodality imaging revealed bilateral pulmonary thromboembolism, severe three-vessel and left main coronary artery disease, alongside massive th…

PMID 42605119 · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

rivaroxaban우선순위 중간ICSR 검토기타

Alpha-1 antitrypsin deficiency associated with increased risk of venous thromboembolism: a nationwide cohort study in Denmark.

Mechanistic investigations suggest that alpha-1 antitrypsin may influence hemostatic processes; however, whether alpha-1 antitrypsin deficiency is associated with an elevated risk of venous thromboembolism is unclear. We tested whether alpha-1 antitrypsin deficiency is associated with venous thromboembolisms in 2 large independent cohorts. In a nationwide…

PMID 42633228 · Research and practice in thrombosis and haemostasis

rivaroxaban우선순위 중간ICSR 검토리뷰

Cutting-Edge Cardiology: Individualizing Antiplatelet Therapy for Optimal Acute Coronary Syndrome Outcomes.

Dual antiplatelet therapy (DAPT), consisting of aspirin and a P2Y12 inhibitor, is fundamental after percutaneous coronary intervention (PCI) in acute coronary syndromes (ACSs). Recent evidence supports moving from a uniform to an individualized approach, tailoring therapy duration and intensity to patient-specific ischemic and bleeding risks. A targeted l…

PMID 42605337 · Cureus

rivaroxaban우선순위 중간ICSR 검토기타

Direct oral anticoagulants in cancer-associated venous thromboembolism: trial robustness and clinical trade-offs.

Although direct oral anticoagulants (DOACs) are often favored over low-molecular-weight heparin for cancer-associated thrombosis, the robustness of trial evidence supporting their use remains uncertain. We evaluated the efficacy, safety, and statistical robustness of DOACs vs dalteparin in patients with cancer-associated venous thromboembolism (VTE). We i…

PMID 42620909 · Research and practice in thrombosis and haemostasis

rivaroxaban우선순위 중간ICSR 검토증례보고

Interventional treatment of a bacterial embolus in the retrohepatic inferior vena cava secondary to invasive Klebsiella pneumoniae liver abscess syndrome: a case report and literature review.

Retrohepatic inferior vena cava (IVC) bacterial embolism secondary to invasive Klebsiella pneumoniae liver abscess syndrome (IKPLAS) is extremely rare, and no English literature has reported its interventional treatment to date. This study presents a detailed case of such interventional treatment, providing references for clinical practice. A 53-year-old…

PMID 42625683 · Frontiers in cardiovascular medicine

rivaroxaban우선순위 중간ICSR 검토체계적 문헌고찰리뷰

Reduced Versus Full Lead-In Apixaban or Rivaroxaban in Acute Venous Thromboembolism: A Systematic Review.

BackgroundDirect oral anticoagulants (DOACs) are recommended as first-line treatment for acute venous thromboembolism (VTE). The recommended regimen of apixaban and rivaroxaban requires a higher-intensity lead-in phase. However, clinicians may use reduced lead-in strategies due to concerns regarding bleeding risk, planned procedures, or prior parenteral a…

PMID 42610841 · Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

semaglutide우선순위 중간ICSR 검토기타

GLP-1 receptor agonist therapy is associated with increased symptomatic remission in ulcerative colitis: a matched cohort study.

Ulcerative colitis (UC) remains associated with significant morbidity despite therapeutic advances. The impact of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) on UC disease activity is not well defined. We performed a retrospective cohort study using electronic health records from a single tertiary academic health system (2022-2024). Adults with…

PMID 42627215 · Inflammatory bowel diseases

semaglutide우선순위 중간ICSR 검토기타

Not Just for Diabetes: The Next Frontier for GLP-1 Agonists.

A commonly used GLP-1 agonist, semaglutide, reduces the risk of adverse cardiovascular outcomes in non-diabetic individuals with obesity and pre-existing cardiovascular disease.

PMID 42624784 · Journal of the American Board of Family Medicine : JABFM

semaglutide우선순위 중간ICSR 검토기타

Psychiatric and eye disorders associated with use of glucagon-like peptide 1 receptor agonists (GLP-1 RAs).

Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) semaglutide, liraglutide, and dulaglutide are indicated for diabetes. Semaglutide and liraglutide were also approved for therapy of obesity or weight control. Apprehension has been expressed about the possible link between GLP-1 RAs and suicidality. Drug agencies established no causal relationship, but…

PMID 42629417 · Naunyn-Schmiedeberg's archives of pharmacology

semaglutide우선순위 중간ICSR 검토증례보고

Semaglutide for Refractory Reactive Hypoglycaemia: A Case Report.

Reactive hypoglycaemia is characterised by symptomatic hypoglycaemia occurring several hours after food intake and can significantly impair quality of life. Management is often challenging, particularly in patients who fail dietary modification or cannot tolerate conventional pharmacological therapies. We present the case of a 50-year-old woman with longs…

PMID 42605357 · Cureus

semaglutide우선순위 중간ICSR 검토증례보고

Severe Gastrointestinal Intolerance After Resuming Maintenance-Dose Semaglutide Following Ramadan-Related Treatment Interruption: A Case Report.

Glucagon-like peptide-1 (GLP-1) receptor agonists are widely used in the treatment of obesity and diabetes mellitus because of their efficacy in weight reduction, glycemic control, and overall metabolic benefits. Gastrointestinal adverse events are among the most frequently reported side effects associated with these agents and are typically transient, oc…

PMID 42622003 · Cureus

semaglutide우선순위 중간ICSR 검토리뷰

The GLP-1-Mitochondria Axis in Metabolic Aging.

Metabolic aging underlies a cluster of chronic conditions-type 2 diabetes, cardiovascular disease, sarcopenia, and neurodegeneration-that account for a substantial share of global morbidity and mortality. A common feature is progressive mitochondrial dysfunction: impaired bioenergetics, disrupted quality control, and loss of metabolic resilience. Reduced…

PMID 42608657 · Aging cell

PMID 42623313 · American journal of physiology. Endocrinology and metabolism

A noninvasive 13 C-mannitol breath test to monitor semaglutide treatment-induced delayed oral-cecal transit in mice.

Glucagon-like peptide-1 receptor agonists (GLP-1RAs), such as semaglutide, are highly effective treatments for obesity and type 2 diabetes but are often associated with gastrointestinal side effects including delayed transit times through the gastrointestinal tract. We present a non-invasive breath test to measure oral-cecal transit time (OCTT) in mice th…

PMID 42604899 · Methods in molecular biology (Clifton, N.J.)

Beyond Small Molecules: Applying Fragment Molecular Orbital Sygnature Platform (FMO-SP) to Emerging Modalities.

Drug discovery is rapidly expanding beyond traditional small molecules to encompass new therapeutic modalities capable of addressing previously "undruggable" targets. Between 2015 and mid-2025, FDA approvals increasingly included biologics and emerging therapeutic modalities such as antibody-drug conjugates (ADCs), nucleic acid therapeutics, and other non…

PMID 42624612 · BMJ mental health

Cognitive signs and symptoms in people with a psychiatric diagnosis on semaglutide: a retrospective cohort study of 13 007 patients in the USA.

Cognitive deficits across psychiatric disorders are common and difficult to treat. Semaglutide, a GLP-1 receptor agonist, shows potential cognitive benefits in diabetes and obesity, but effects in psychiatric populations remain unclear. To determine whether initiation of semaglutide is associated with fewer cognitive signs/symptoms over 12 months among ad…

PMID 42623535 · Diabetes care

Comment on Klein et al. Safety of Semaglutide After Dialysis Initiation: An Individual-Level Pooled Analysis.

PubMed에 초록이 제공되지 않았습니다.

PMID 42612445 · Social science & medicine (1982)

Compounding stigma: An experimental study comparing perceptions of an individual using Ozempic, bariatric surgery, or behavior modification.

Weight loss is a billion-dollar industry; methods of weight loss influence weight stigma and person perception. Prior research suggests individuals undergoing bariatric surgery face compounding prejudice from both their physical condition and the surgery itself. Bariatric surgery is often viewed as "taking the easy way out." Emerging evidence reveals simi…

Daily briefing: Narcolepsy drug could kick off an Ozempic-style moment for the brain.

PubMed에 초록이 제공되지 않았습니다.

PMID 42613446 · Nature

PMID 42608058 · BMJ (Clinical research ed.)

Doctor who prescribed Ozempic and Wegovy to her partner has suspension extended.

PubMed에 초록이 제공되지 않았습니다.

PMID 42604953 · The International journal of eating disorders

Exploring Perspectives on Ozempic: A Netnographic Qualitative Evaluation of the Pro-Eating Disorder Community on X (Formerly Twitter).

Eating disorders (EDs) are complex conditions with medical and psychosocial implications. Social media (SM) exposure has been associated with increased body image concerns and maladaptive eating behaviors. Pro-eating disorder (pro-ED) communities exist across SM platforms and often perpetuate ED-related identities and behaviors. As Ozempic gains prominenc…

semaglutide우선순위 낮음근거 검토리뷰

Hepatology: Emerging Paradigms in MASLD, Viral Hepatitis, Cholestatic Liver Disease, Portal Hypertension and Hepatocellular Carcinoma: Summary of the First Annual Paris International Liver Meeting 2026.

The Paris International Liver Meeting (January 19-21, 2026) brought together leading hepatology experts to discuss transformative advances in chronic liver disease management. The meeting highlighted pivotal developments reflecting the field's evolution from disease characterisation toward precision, mechanism-based therapeutics. Metabolic dysfunction-ass…

PMID 42613687 · Liver international : official journal of the International Association for the Study of the Liver

PMID 42631177 · ACS measurement science au

Native Mass Spectrometry of Soluble Proteins with Sodium Chloride Enabled by a Dendritic Detergent.

Salts are essential for maintaining native protein structure and biomolecular interactions. Native mass spectrometry often yields uninterpretable spectra due to salt adduction and signal suppression. Existing workarounds require buffer exchange or extensive cleanup, which can disrupt weak noncovalent interactions and reduce throughput. Addressing this sho…

PMID 42622205 · Postgraduate medicine

Oral semaglutide for obesity: clarifying comparative evidence and real-world applicability.

PubMed에 초록이 제공되지 않았습니다.

PMID 42622752 · Internal and emergency medicine

Oral semaglutide vs DPP-4 inhibitors in reducing risk of cognitive impairment in elderly patients with HFpEF and obesity.

Heart failure with preserved ejection fraction (HFpEF), obesity, type 2 diabetes mellitus are common in elderly patients and are associated with an increased risk of cognitive impairment (CoI). In these patients, the protective metabolic and vascular effects of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are well established. The aim of this stu…

PMID 42620396 · Frontiers in public health

Quality and reliability of semaglutide-related health information on Chinese short-video platforms: a cross-sectional study of Bilibili and TikTok.

Semaglutide, a glucagon-like peptide-1 receptor agonist originally developed for glycemic control, has recently gained widespread attention for its weight-loss effects. With the rapid rise of short-video platforms, these media have become important channels for disseminating health information. However, the quality, reliability, and underlying determinant…

PMID 42633295 · Drug design, development and therapy

Response to "Semaglutide in Diabetic Periodontitis-Induced Osteoblast Ferroptosis: Pharmacological and Methodological Insights" [Response to Letter].

PubMed에 초록이 제공되지 않았습니다.

PMID 42623532 · Diabetes care

Response to Comment on Klein et al. Safety of Semaglutide After Dialysis Initiation: An Individual-Level Pooled Analysis.

PubMed에 초록이 제공되지 않았습니다.

semaglutide우선순위 낮음근거 검토동물시험

Semaglutide Alleviates LPS-Induced Cognitive Disorder via O-GlcNAcylation of AKT-mTOR Signaling Pathway Components.

Perioperative neurocognitive disorder (PND) manifests as neurocognitive alterations induced by anesthesia and surgical stress. High-risk factors, including advanced age, obesity, diabetes, and preoperative neurological dysfunction, accelerate PND progression, with neuroinflammation serving as a core pathological mechanism throughout PND pathogenesis. Sema…

PMID 42622904 · Neuromolecular medicine

semaglutide우선순위 낮음근거 검토체계적 문헌고찰리뷰

Semaglutide-Induced Nonarteritic Anterior Ischemic Optic Neuropathy: A Systematic Review and Meta-Analysis.

Despite the recent reports of the potential association between semaglutide and nonarteritic anterior ischemic optic neuropathy (NAION), available evidence remains inconclusive. We aimed to evaluate the relative effect (RE) of NAION in individuals treated with semaglutide compared to the control group. The results of this systematic review and meta-analys…

PMID 42612051 · Journal of clinical pharmacology

PMID 42610056 · Diabetes, metabolic syndrome and obesity : targets and therapy

Serum GDF3 is Associated with Visceral Obesity, Insulin Resistance, and Inflammation in Non-Diabetic Adults: A Cross-Sectional Study with an Interventional Component.

Growth differentiation factor 3 (GDF3), a TGFβ superfamily cytokine, has been linked to visceral adipose proliferation and adiposity in animal studies. However, the relationship between circulating GDF3 levels and visceral adiposity in humans remains unclear. This study aimed to assess the potential of serum GDF3 as a biomarker for visceral obesity. This…

semaglutide우선순위 낮음근거 검토리뷰

Targeting Overweight and Obesity Phenotypes for Secondary Prevention of Cardiovascular Disease: A Call to Action for the Middle East and Beyond.

Although there are conflicting clinical data on the efficacy of weight reduction in reducing secondary events in patients with comorbid overweight and obesity (OAO) and cardiovascular disease (CVD), there is excellent epidemiological and biological evidence of a cause-effect relationship between OAO, CVD, and other systemic complications. There is also ne…

PMID 42634097 · Obesity reviews : an official journal of the International Association for the Study of Obesity

tirzepatide우선순위 중간ICSR 검토체계적 문헌고찰리뷰

Efficacy and safety of different once-weekly glucagon-like peptide-1 receptor agonists-A systematic review and Bayesian network meta-analysis.

There are less comparisons among once-weekly glucagon-like peptide-1 receptor agonists (GLP-1RAs),which is not conducive to refined clinical treatment. We searched in Pubmed, Embase, and Cochrane Central Register of Controlled Trials from database creation date to June 1, 2024. The primary glycemic efficacy was changes from baseline to endpoint for HbA1c.…

PMID 42618994 · Diabetes research and clinical practice

tirzepatide우선순위 중간ICSR 검토리뷰

GLP-1 and dual GIP/GLP-1 receptor agonists' psychopharmacology and putative neuropsychiatric associated effects: a Bradford Hill-informed, systematic, evaluation.

This review evaluates evidence linking both GLP-1 and GIP/GLP-1RAs' exposure to a range of neuropsychiatric outcomes using the Bradford Hill criteria for causal inference. Glucagon-like peptide-1 (GLP-1) and the dual glucose-dependent insulinotropic polypeptide-GIP/GLP-1 receptor agonists (RAs) are incretin-based medications widely prescribed for type 2 d…

PMID 42624955 · Current psychiatry reports

tirzepatide우선순위 중간ICSR 검토리뷰

GLP-1 Receptor Agonists and Alopecia: A Systematic Review and Meta-Analysis of Incidence, Risk, Subtypes, and Mechanisms.

GLP-1 receptor agonists (GLP-1 RAs) are among the fastest-growing pharmacological classes globally. Alopecia has emerged as a clinically relevant adverse effect signal, yet pooled quantitative estimates of risk by subtype and agent are lacking. The objective of this study was to estimate the pooled risk of alopecia associated with GLP-1 RA use, stratified…

PMID 42621629 · Skin appendage disorders

tirzepatide우선순위 중간ICSR 검토기타

Increasing skeletal muscle mass and strength during incretin-based weight loss.

Incretin-based therapies produce robust weight loss in obesity and type 2 diabetes mellitus (T2DM), but some weight lost is lean body mass (LBM), raising concern about sarcopenia and functional decline. Men with obesity or type 2 diabetes (T2DM) and testosterone deficiency may lose skeletal muscle mass (SMM) during weight reduction. Whether a program inco…

PMID 42620560 · Obesity pillars

tirzepatide우선순위 중간ICSR 검토증례보고

Severe Dumping and Persistent Obesity in a Post-Roux-en-Y Gastric Bypass Patient With a Non-discernible Gastric Pouch and Symptomatic Improvement on Tirzepatide: A Case Report.

Rapid transit of ingested nutrients into the small bowel following gastric or esophageal surgery can trigger dumping syndrome, a recognized postoperative complication seen with particular frequency after Roux-en-Y gastric bypass (RYGB). Under normal operative conditions, RYGB constructs a proximal gastric pouch that serves to limit meal volume and pace nu…

PMID 42634712 · Cureus

tirzepatide우선순위 중간ICSR 검토기타

Sex-based differences in clinical outcomes among patients with obesity and heart failure with preserved ejection fraction treated with tirzepatide.

BackgroundSex-related differences are well recognized in heart failure with preserved ejection fraction (HFpEF), but real-world data describing clinical outcomes by sex among patients with obesity and HFpEF treated with tirzepatide remain limited.ObjectivesTo compare observed hospitalization, cardiovascular, and gastrointestinal outcomes between male and…

PMID 42605954 · Therapeutic advances in cardiovascular disease

tirzepatide우선순위 중간ICSR 검토리뷰

The Neuroprotective Potentials of Dual GIP/GLP1-RA (Tirzepatide): From Preclinical Experiments to Clinical Trials: A Scoping Review.

Tirzepatide (TZP), the first approved dual glucagon-like peptide 1 (GLP-1)/glucose-dependent insulinotropic polypeptide (GIP) agonist, has shown neuroprotective effects in preclinical models and early observational studies. This review maps and appraises current preclinical and clinical evidence on TZP's potential neuroprotective effects in neurodegenerat…

PMID 42608956 · Brain and behavior

PMID 42627907 · Science advances

A multi-functional oral small molecule targeting energy and lipid metabolism to treat obesity and related metabolic disorders.

Obesity and related metabolic disorders have surged globally, and are mechanistically interconnected through dysregulated energy and lipid metabolism pathways. Current incretin-based obesity treatments act to decrease food intake, but are associated with gastrointestinal side effects and muscle wasting. Here, we identified an orally bioavailable multi-fun…

PMID 42630863 · Obesity science & practice

Attitudes Toward Injectable GLP-1 Drugs for Obesity Treatment: A Qualitative Interview Study With Healthcare Professionals.

Injectable GLP-1 drugs such as semaglutide (Wegovy) and tirzepatide (Mounjaro, a dual GLP-1 and GIP receptor agonist) can help individuals living with obesity to lose weight. UK guidelines currently recommend semaglutide and other injectable GLP-1 drugs are prescribed in specialist (Tier 3) multidisciplinary weight management services, and other settings.…

PMID 42618422 · Journal of diabetes and its complications

Clinical efficacy of switching to tirzepatide in patients with type 2 diabetes and a high risk of metabolic dysfunction-associated steatotic liver disease undergoing GLP-1 receptor agonist therapy: Insights from the Hokkaido-TZP study.

To evaluate the clinical efficacy of switching from glucagon-like peptide-1 receptor agonists (GLP-1RAs) to tirzepatide in terms of metabolic and hepatic indices in patients with T2D at high risk of metabolic dysfunction-associated steatotic liver disease (MASLD). This multicenter, retrospective study comprised secondary analysis of the Hokkaido-TZP study…

PMID 42623541 · Diabetes care

Comment on Ostrominski et al. Comparative Effectiveness of Tirzepatide Versus Dulaglutide or Semaglutide on Major Cardiovascular Events in Type 2 Diabetes and Cardiovascular Disease: Insights From Two Target-Trial Emulations.

PubMed에 초록이 제공되지 않았습니다.

Comparative effects of semaglutide tirzepatide and retatrutide on renal fibrosis in UUO and aged mice.

Chronic kidney disease is a major health burden. Given the therapeutic potential of GLP-1 receptor agonists (semaglutide, tirzepatide, and retatrutide) in diabetic nephropathy, we evaluated their anti-fibrotic and anti-inflammatory effects in non-diabetic renal fibrosis using HK-2 cells and murine UUO and aging models. Integrating in vivo and in vitro dat…

PMID 42630988 · iScience

PMID 42610030 · Diabetes, metabolic syndrome and obesity : targets and therapy

Comparative Efficacy of Semaglutide and Tirzepatide in Chinese Adults with Obesity without Diabetes: A Real-World Observational Study.

To conduct a direct comparison of the effects of Semaglutide and Tirzepatide among adults with obesity but without diabetes. From January 2024 to February 2026, a total of 183 Chinese adults were enrolled from the obesity clinic at our hospital in a single-center, retrospective observational cohort study. All participants received either once-weekly Semag…

PMID 42625929 · World journal of clinical pediatrics

Current and forthcoming pharmacotherapies for adolescent obesity: Evidence-based review.

The prevalence of adolescent obesity has increased substantially in recent decades. This disease affects more than 20% of young people. Obesity is associated with metabolic disorders and heart disease. Conservative treatments are not effective in severe obesity. Therefore, this minireview aims to compare and clarify the effectiveness of treatments. It als…

PMID 42627149 · Journal of the European Academy of Dermatology and Venereology : JEADV

GLP-1 and GLP-1/GIP agonists in psoriasis: A real-world cohort study on healthcare resource usage.

PubMed에 초록이 제공되지 않았습니다.

Glucagon-like peptide-1 receptor agonists in idiopathic intracranial hypertension: A systematic review and meta-analysis.

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), initially developed for type 2 diabetes and obesity, have emerged as promising candidates for idiopathic intracranial hypertension (IIH) due to their metabolic and neurophysiological effects. This systematic review and meta-analysis aims to summarize, synthesize, and quantitatively pool the available…

PMID 42619634 · Headache

PMID 42626264 · World journal of methodology

Glucagon-like receptor-1 agonists and impotence: A meta-analysis.

Glucagon-like peptide receptors-1 agonists (GLP-1 agonists) have revolutionized the treatment of obesity and diabetes due to their potent effects on weight and glycemic control, and cardiorenal protection. However, emerging reports and post-marketing surveillance have raised concerns regarding erectile dysfunction (ED) or impotence in a subset of male pat…

PMID 42626202 · World journal of methodology

Pancreatic-liver crosstalk, novel molecular mediators, and 2025 therapeutic breakthroughs.

Obesity, a global public health crisis driven by dysregulated systemic energy homeostasis, is increasingly recognized as a disorder of interorgan communication, with the pancreas and liver serving as central interconnected metabolic hubs. Their bidirectional crosstalk, mediated through neural and humoral pathways, is a key driver of disease progression. R…

Practical considerations for the use of incretin mimetics in patients with neuroendocrine neoplasms: An expert consensus statement.

Incretin-based therapies, including glucagon-like peptide-1 receptor agonists (GLP-1RA) and dual incretin agonists, are increasingly used for the management of diabetes, obesity, and cardiometabolic disease. Although their systemic benefits are well established, uncertainty remains regarding their safety in patients with neuroendocrine neoplasms (NENs), a…

PMID 42606162 · Cancer

PMID 42634284 · Diabetes, obesity & metabolism

Responders Vs. Non-Responders or How to Predict the Response to GLP-1 or GLP-1/GIP Receptor Agonist Therapy.

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and dual GLP-1/GIP receptor agonists have transformed the pharmacological management of type 2 diabetes (T2D) and obesity, yet substantial interindividual variability in treatment response remains a defining clinical challenge. Narrative review. PubMed was searched to 25 May 2026 (English language, huma…

PMID 42624330 · Diabetes research and clinical practice

Trends in utilization of glucagon-like peptide‑1 receptor agonists, sodium-glucose cotransporter‑2 inhibitors, and metabolic bariatric surgery in U.S. Adults with diabetes and obesity.

To characterize trends in utilization of glucagon-like peptide‑1 receptor agonists (GLP‑1RAs), sodium-glucose cotransporter‑2 inhibitors (SGLT2is), and metabolic/bariatric surgery among US adults with type 2 diabetes (T2D) and obesity. We conducted a cohort study using electronic health record and claims data from Optum Labs Data Warehouse for US private…

PMID 42634315 · Cardiovascular & hematological disorders drug targets

Venous Congestion in Metabolic Heart Disease: Potential Indirect Role of Dual Incretin Agonists.

Venous congestion is responsible for symptoms, organ dysfunction, and negative outcomes in heart failure. In obesity-related Heart Failure (HF) with preserved ejection fraction (HFpEF), metabolic dysfunction, inflammation, endothelial damage, and sodium retention might exacerbate venous congestion. This structured narrative review provides an overview of…

PMID 42619286 · European heart journal

Weekly Journal Scan: SURMOUNT and MAINTAIN the summit: tirzepatide after successful bodyweight loss.

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PMID 42634795 · Journal of the Endocrine Society

Weight loss outcomes with tirzepatide in women with and without self-reported polycystic ovary syndrome.

Weight management is key to managing polycystic ovary syndrome (PCOS) and overweight/obesity but is challenging for many. Evidence regarding tirzepatide's efficacy in women with polycystic ovary syndrome is limited. To quantify the effectiveness of tirzepatide for weight loss in women with (self-reported) polycystic ovary syndrome and overweight/obesity c…

tofacitinib우선순위 중간ICSR 검토증례보고

Tocilizumab-induced inflammatory flare in Takayasu arteritis: a case report with exploratory mechanistic findings of Fcγ receptor involvement.

To report a refractory Takayasu arteritis (TAK) patient who developed a severe inflammatory flare after tocilizumab (TCZ) therapy and explore the underlying mechanism. A 21-year-old female with active TAK received TCZ after insufficient response to prednisone. TCZ was temporarily withheld then re-added at 400 mg due to disease relapse. After TCZ reintrodu…

PMID 42614358 · Frontiers in immunology

tofacitinib우선순위 중간ICSR 검토기타

Tofacitinib demonstrates favorable efficacy but an increased risk of herpes zoster in elderly patients with rheumatoid arthritis: a retrospective cohort analysis.

To evaluate the efficacy of tofacitinib in elderly patients with rheumatoid arthritis (RA) and analyze herpes zoster risk factors. A retrospective analysis included elderly RA patients from January 2022 to June 2024. Patients were assigned to a tofacitinib group (n=62, tofacitinib + methotrexate) or a conventional disease-modifying antirheumatic drugs (DM…

PMID 42631130 · American journal of translational research

tofacitinib우선순위 낮음근거 검토기타

Comparison of efficacy and safety of oral corticosteroid mini pulse versus oral tofacitinib in stabilization of active vitiligo: A 24-week randomized controlled assessor-blinded clinical trial with evaluation of serum IL-6 as a surrogate marker.

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PMID 42628800 · Journal of the American Academy of Dermatology

valproate우선순위 중간ICSR 검토기타

Cell-based Therapies and Drug Repurposing in Stroke.

Ischemic stroke is a leading cause of death and disability worldwide, and contributes substantially to the global burden of disease. Although reperfusion therapies such as intravenous thrombolysis with recombinant tissue plasminogen activator (rt-PA) and mechanical thrombectomy have transformed acute management, the stringent eligibility criteria, narrow…

PMID 42633921 · Journal of Nippon Medical School = Nippon Ika Daigaku zasshi

valproate우선순위 중간ICSR 검토기타

Cost-Effectiveness and Cost-Utility Analysis of Cinnarizine Compared to Valproate in Pediatric Migraine: An Iranian Perspective.

Childhood migraine is a prevalent neurovascular disease in children with a considerable reduction in quality of life and high social cost. Anticonvulsants, such as Valproate and calcium channel blockers, including Cinnarizine are used frequently as preventive medications. This research evaluates the cost-effectiveness and cost-utility of Cinnarizine versu…

PMID 42626205 · Iranian journal of child neurology

valproate우선순위 중간ICSR 검토증례보고

Unmasked Behavioral Disturbance Following Traumatic Brain Injury in an Adult With Previously Undiagnosed Sotos Syndrome.

Sotos syndrome is a rare autosomal dominant disorder characterized by childhood overgrowth, including tall stature and macrocephaly, distinctive facial appearance, and neuropsychiatric manifestations. These features include intellectual disability and a broad spectrum of behavioral disturbances. Traumatic brain injury (TBI) is also known to cause various…

PMID 42621581 · Cureus

valproate우선순위 중간ICSR 검토증례보고

When Surgical Intervention Becomes a Risk: Severe Drug-Induced Gingival Overgrowth and Clinical Decision-Making in Alpers-Huttenlocher Syndrome.

Alpers-Huttenlocher syndrome (AHS) is an ultra-rare, autosomal recessive mitochondrial encephalopathy caused by pathogenic POLG variants, characterized by refractory epilepsy, hepatic dysfunction, and progressive neurodegeneration. Drug-induced gingival overgrowth (DIGO) is a recognized complication of anticonvulsant and immunosuppressive therapy, particu…

PMID 42635616 · Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry

PMID 42633072 · Translational neuroscience

A comparative study of the impact of maternal immune activation and valproic acid on autism-like behavior in rats.

The present study aimed to evaluate the behavioral consequences of maternal immune activation (MIA) induced by lipopolysaccharide (LPS), in comparison to valproic acid (VPA), a widely used and reliable inducer of autism-like features in rats when administered during prenatal development. At the behavioral level, we further assessed the potential ameliorat…

PMID 42625357 · Journal of the Royal Society of Medicine

Accountability for AI harms? Lessons from valproate.

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PMID 42634932 · Drug metabolism and personalized therapy

Assessment of the impact of valproic acid co-administration on clozapine plasma concentrations in Tunisian patients.

Reports on drug-drug interactions between Valproic Acid (VPA) and Clozapine (CLZ) are very inconsistent. Previous reports demonstrate that VPA may exhibit either inhibitory or inductive effects or have no effect on CLZ pharmacokinetics. The aim of this study was to investigate the impact of VPA on plasma CLZ concentrations in a series of Tunisian patients…

PMID 42627711 · Epilepsia open

valproate우선순위 낮음근거 검토리뷰

Attitudes toward sodium valproate use, withdrawal, and counseling in people of reproductive potential: A scoping review.

Regulatory restrictions and evolving clinical guidelines have aimed to reduce sodium valproate use in people of reproductive potential over the past decade due to its teratogenic risk. While clinical evidence and policy responses are well established, stakeholder perspectives remain less explored. This scoping review synthesizes the existing evidence on t…

PMID 42624443 · Journal of ethnopharmacology

Bioactivity-guided isolation of anticonvulsant and anxiolytic constituents from Stachys and Teucrium species.

Species of the genera Stachys L. and Teucrium L. (Lamiaceae) have been traditionally used in folk medicine for the management of neurological disorders, including epilepsy and anxiety. However, experimental evidence supporting these traditional claims remains limited for several taxa. The present study aimed to evaluate the anticonvulsant and anxiolytic a…

PMID 42621753 · Biomolecules & biomedicine

Black mulberry fruit extract attenuates valproic acid-induced toxicity by enhancing antioxidant defenses in FaO cells.

Valproic acid (VPA) is widely used to treat neurological and psychiatric disorders but may cause hepatotoxicity partly through oxidative stress and impaired cellular metabolism. This study investigated whether black mulberry (Morus nigra L.) fruit extract attenuates VPA-induced injury in rat FaO hepatoma cells. Cells were exposed to VPA acutely (500 μg/mL…

PMID 42606530 · Drug development research

Development of Phenoxyacetic Acid Hybrids With COX-2 Inhibitory Activity as Potential Anti-Neuroinflammatory Agents.

This research employs a molecular hybridization strategy to repurpose the pyrazoline scaffold 6a, 6c, 7a-c, 11a, and 12b, transforming it into a high-efficiency conjugate designed to tackle the multifaceted pathology of neuroinflammation and epilepsy. By integrating a selective phenoxyacetic acid moiety. Our findings identified compound 7c as a potential…

PMID 42628487 · Computational biology and chemistry

Identification of the M1-like macrophage-associated diagnostic and therapeutic frameworks targeting carotid atherosclerosis patients: Integrative bioinformatic and multi-omic studies.

M1‑like macrophage dysregulation is a central driver of inflammation and plaque formation in atherosclerosis (AS). However, specific diagnostic and therapeutic targets for carotid atherosclerotic plaque remain incomplete. This study aims to identify M1‑like macrophage‑associated diagnostic biomarkers and potential therapeutic compounds for carotid atheros…

PMID 42632396 · Psychiatry research

Integrated network pharmacology and lipidomics provide insights into potential mechanisms underlying the effects of cannabidiol in a rat model of autism.

Cannabidiol (CBD) has shown potential benefits in managing symptoms associated with autism spectrum disorder (ASD), although its underlying mechanisms of action remain unclear. This study investigated whether CBD improves ASD-like behavior in association with changes in lipid metabolic disturbances and apoptosis-related signaling in a prenatal valproic ac…

PMID 42624452 · European journal of pharmacology

Intergenerational Consequences of Valproic Acid Exposure: Dose- and Sex-Specific Effects in Drosophila melanogaster.

Valproic acid (VPA) is a widely used anticonvulsant and mood stabilizer, that is notable for its role as histone deacetylase (HDAC) inhibitor and its potential impact on epigenetic modulation. However, its intergenerational impacts are not fully understood. In this study, we investigated the dose- and sex-dependent intergenerational effects of VPA using D…

PMID 42622404 · Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

Male use of valproate - regulation before evidence?

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PMID 42608304 · Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

[Clinical characteristics, diagnosis, and treatment of 40 cases of venous thrombotic disease in children at a single center].

To investigate the clinical characteristics, diagnostic approach, multidisciplinary diagnosis and treatment model, and anticoagulation strategies of venous thrombotic disease in children, summarize diagnosis and treatment experience, and provide a reference for improving standardized management of this condition. A retrospective analysis was conducted on…

PMID 42605030 · Internal medicine journal

Anticoagulation stewardship team oversight of enoxaparin-warfarin bridging delivered by Hospital in the Home: a pre- and post-implementation study.

Initiation or re-initiation of warfarin often requires enoxaparin bridging, a period associated with increased bleeding risk. Anticoagulation stewardship (ACS) teams may improve the safety of anticoagulant management; however, their impact on bridging delivered by Hospital in the Home (HITH) is unknown. To determine the impact of ACS-guided anticoagulatio…

PMID 42625323 · Journal of pharmacy practice

Case Report: Direct Oral Anticoagulants Treatment Failure for Venous Thromboembolism in the Setting of Multiple Thrombophilic Conditions.

This case report describes the treatment failure of two direct oral anticoagulants (DOACs) in a patient with multiple thrombophilic conditions, including triple-positive antiphospholipid syndrome (APS) and heterozygous Factor V Leiden mutation. A 69-year-old male with a history of recurrent venous thromboembolism developed a deep vein thrombosis while rec…

Clinical Profile, Management Patterns, and In-Hospital Outcomes Among Patients Hospitalized With Atrial Fibrillation at a Tertiary Care Hospital: A Single-Center Retrospective Study.

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia worldwide and is associated with substantial morbidity, mortality, recurrent hospitalization, and healthcare expenditure. This study aimed to evaluate the clinical characteristics, management patterns, and in-hospital outcomes of patients hospitalized with AF and to identify factors…

PMID 42621371 · Cureus

warfarin우선순위 중간ICSR 검토증례보고

Concomitant Aortic Valve Neocuspidization and Resection of a Cardiac Calcified Amorphous Tumor in a Hemodialysis Patient: A Case Report.

Cardiac calcified amorphous tumor (CAT) is an uncommon nonneoplastic intracardiac lesion associated with end-stage renal disease; mobile lesions carry an embolic risk and are generally resected. A 62-year-old man on maintenance hemodialysis was found to have a mobile verrucous mass 17 mm long on the anterior mitral leaflet and a separate immobile calcifie…

PMID 42605260 · Cureus

Direct Oral Anticoagulants Compared to Warfarin Early After Cardiac Surgery: A Pilot Randomized Controlled Trial.

The goal was to conduct a pilot randomized controlled trial (RCT) of direct oral anticoagulants (DOACs) early after cardiac surgery to determine the feasibility of a larger RCT. We conducted an open-label, 2-site, pilot RCT of adults undergoing cardiac surgery with an indication for anticoagulation, excluding mechanical valves and bioprosthetic mitral val…

PMID 42610036 · CJC open

warfarin우선순위 중간ICSR 검토증례보고

Massive aortic thrombus in a hypercoagulable patient with heparin induced thrombocytopenia: a case report.

Large ascending aortic thrombus can lead to devastating consequences and requires astute recognition and evaluation, systemic anticoagulation, and urgent surgical intervention. Perioperative and surgical management of a large ascending aortic thrombus is further complicated in patients who develop heparin induced thrombocytopenia (HIT) as the risks of fur…

PMID 42630987 · Journal of surgical case reports

PMID 42620337 · medRxiv : the preprint server for health sciences

Peri-Procedural Healthcare Costs of Thromboembolic and Bleeding Events in Patients on Direct Oral Anticoagulants Undergoing High-Risk Endoscopy.

Patients on direct oral anticoagulants (DOACs) undergoing high-risk endoscopy face competing risks of bleeding and thromboembolism during peri-procedural anticoagulant interruption. We quantified peri-procedural adverse event (AE) rates and incremental healthcare costs. Retrospective cohort study using the TriNetX Linked Claims database (2015-2025), a US-…

PMID 42628015 · ASAIO journal (American Society for Artificial Internal Organs : 1992)

Real-World Hemocompatibility Outcomes With Aspirin Omission in a Novel Fully Magnetically Levitated Left Ventricular Assist Device.

Evidence from the fully magnetically levitated HeartMate 3 has suggested that aspirin omission may be safe and potentially beneficial. CH-VAD, a novel fully magnetically levitated ventricular assist device, has historically used standard anticoagulation protocols. This multicenter, retrospective study aimed to assess the impact of aspirin omission on hemo…

warfarin우선순위 중간ICSR 검토체계적 문헌고찰

Safety and efficacy of direct acting oral anticoagulants in the treatment of patients with morbid obesity with venous thromboembolism: A meta-analysis.

Direct acting oral anticoagulants (DOACs) are widely utilized in the management of venous thromboembolism. Numerous studies have demonstrated that their safety and efficacy surpass those of warfarin. Nevertheless, the evidence supporting their use in treating venous thrombosis among patients with morbid obesity remains inadequate, necessitating further in…

PMID 42629703 · Medicine

PMID 42622759 · Journal of thrombosis and thrombolysis

warfarin우선순위 중간ICSR 검토리뷰

Venous thromboembolism prophylaxis in multiple myeloma patients receiving immunomodulatory therapy: a systematic review and meta-analysis.

Patients with multiple myeloma receiving immunomodulatory drugs have an increased risk of venous thromboembolism (VTE), but the comparative effectiveness and safety of available prophylactic strategies remain uncertain. A systematic review and meta-analysis of randomized and prospective studies was conducted in accordance with PRISMA 2020. Studies evaluat…

PMID 42615395 · Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

warfarin우선순위 낮음근거 검토기타

Factors Associated With Time in Therapeutic Range Among Thai Patients with Non-valvular Atrial Fibrillation Taking Warfarin: Development of AHfHDP Score.

BackgroundIn Thai patients with non-valvular atrial fibrillation (NVAF), anticoagulation quality with warfarin remains suboptimal. Existing prediction tools for poor international normalized ratio (INR) control, such as the SAMe-TT 2 R 2 score, perform poorly in this population. Identifying population-specific determinants of time in therapeutic range (TT…