문헌 01warfarinICSR 검토우선순위 중간
Drug-Drug Interaction Signals for Major Bleeding in Nursing Home Residents: High-Throughput Screening of Clopidogrel and Oral Anticoagulants.
Nursing home (NH) residents are at high risk for major bleeding and are frequently exposed to complex medication regimens that may increase the likelihood of clinically important drug-drug interactions (DDIs). However, DDI evidence from community-dwelling populations may not generalize to NH reside…
PMID42494112DOI10.1002/pds.70441연구 유형기타학술지Pharmacoepidemiology and drug safety
https://pubmed.ncbi.nlm.nih.gov/42494112/문헌 02dabigatranICSR 검토우선순위 중간
A first-in-human study evaluating safety, PK, and PD of a novel universal anticoagulant reversal agent, OKL-1111.
OKL-1111 is a small-molecule γ-cyclodextrin universal reversal agent for anticoagulants and platelet inhibitors that was being developed to significantly shorten time to treatment for intracerebral hemorrhage. Part A of this single-center, randomized, placebo-controlled, double-blind, single-ascend…
PMID42438486DOI10.1016/j.bvth.2026.100176연구 유형기타학술지Blood vessels, thrombosis & hemostasis
https://pubmed.ncbi.nlm.nih.gov/42438486/문헌 03warfarinICSR 검토우선순위 중간
Apixaban versus warfarin for anticoagulation after left ventricular assist device implantation: A multicenter real-world analysis.
Anticoagulation is standard in patients with left ventricular assist devices (LVADs), but the optimal regimen remains uncertain. While warfarin has historically been utilized, the use of direct oral anticoagulants is increasing. Using the TriNetX Collaborative Research Network, we identified adult…
PMID42211992DOI10.1016/j.jhlto.2026.100567연구 유형기타학술지JHLT open
https://pubmed.ncbi.nlm.nih.gov/42211992/문헌 04edoxabanICSR 검토우선순위 중간
Dramatically changing intracranial arteriopathy due to antiphospholipid syndrome: A case report.
Antiphospholipid syndrome (APS) is an autoimmune thrombophilia that rarely presents with progressive intracranial large-artery stenosis or occlusion, making early recognition difficult when vascular lesions mimic atherosclerotic disease. A 74-year-old female receiving edoxaban for atrial fibrillati…
PMID42111407DOI10.1016/j.radcr.2026.03.071연구 유형기타학술지Radiology case reports
https://pubmed.ncbi.nlm.nih.gov/42111407/문헌 05warfarin근거 검토우선순위 낮음
Clinical outcomes of direct oral anticoagulants versus warfarin for ischemic stroke caused by left ventricular thrombus: A retrospective one-center study.
LVT is a leading etiology of cardioembolic stroke, and appropriate anticoagulation therapy is essential. However, the choice of anticoagulant in LVT patients remains based on the individual patient and physician. The objective of this study is to evaluate the relative clinical outcomes of warfarin…
PMID41996969DOI10.1016/j.clineuro.2026.109432연구 유형기타학술지Clinical neurology and neurosurgery
https://pubmed.ncbi.nlm.nih.gov/41996969/문헌 06apixabanICSR 검토우선순위 중간
Comparing Hemostatic Efficacy of Four-factor Prothrombin Complex Concentrate with Andexanet Alfa in an Apixaban-treated Polytrauma Male Porcine Model.
This study directly compared the hemostatic efficacy of two first-line treatments for reversing the effects of direct oral anticoagulants in patients with massive bleeding, andexanet alfa and four-factor prothrombin complex concentrate (4F-PCC), in an apixaban anticoagulated male porcine polytrauma…
PMID41983565DOI10.1097/ALN.0000000000006095연구 유형기타학술지Anesthesiology
https://pubmed.ncbi.nlm.nih.gov/41983565/문헌 07warfarinICSR 검토우선순위 중간
Anticoagulation approaches in hemodialysis: a systematic review of efficacy, safety, and literature gap.
Anticoagulation is essential in hemodialysis (HD) to maintain circuit patency and reduce thromboembolic risk. Common options include unfractionated heparin (UFH), low-molecular-weight heparin (LMWH), regional citrate anticoagulation (RCA), and direct oral anticoagulants (DOACs). This review synthes…
PMID41621041DOI10.1007/s11255-026-05034-2연구 유형기타학술지International urology and nephrology
https://pubmed.ncbi.nlm.nih.gov/41621041/문헌 08rivaroxabanICSR 검토우선순위 중간
Dieulafoy's Lesion of the Major Duodenal Papilla Presenting as Obscure Upper Gastrointestinal Bleeding: A Case Report.
Dieulafoy's lesion is an uncommon vascular anomaly that can cause life-threatening gastrointestinal bleeding. While the stomach is the most frequently affected site, involvement of the major duodenal papilla is exceedingly rare and may escape detection with conventional forward-viewing endoscopy. W…
PMID42516248DOI10.1002/ccr3.73203연구 유형기타학술지Clinical case reports
https://pubmed.ncbi.nlm.nih.gov/42516248/문헌 09rivaroxabanICSR 검토우선순위 중간
Current practices of index hospitalization anticoagulant use in pediatric patients with acute myeloid leukemia.
Management and prevention of thromboembolism (TE) in pediatric acute myeloid leukemia (AML) are challenging because of prolonged periods of thrombocytopenia and associated bleeding. There are no guidelines for prophylactic or therapeutic anticoagulation for children with AML. This study aimed to un…
PMID42500325DOI10.1016/j.bvth.2026.100178연구 유형기타학술지Blood vessels, thrombosis & hemostasis
https://pubmed.ncbi.nlm.nih.gov/42500325/문헌 10rivaroxaban근거 검토우선순위 낮음
Sonocrystallization approach in crystal habit modification for improving the pharmaceutical properties of Rivaroxaban.
Poor pharmaceutical material properties of active pharmaceutical ingredients (APIs) can result in suboptimal manufacturing and therapeutic outcomes. Rivaroxaban (RIV) was explored as a model API due to its poor pharmaceutical properties and challenging industrial processability. In this research, c…
PMID42276017DOI10.1016/j.ultsonch.2026.107921연구 유형기타학술지Ultrasonics sonochemistry
https://pubmed.ncbi.nlm.nih.gov/42276017/문헌 11rivaroxaban근거 검토우선순위 낮음
Spontaneous Neonatal Aortic Thrombosis Successfully Treated With Rivaroxaban.
PubMed에 초록이 제공되지 않았습니다.
PMID42135985DOI10.1002/1545-5017.70403연구 유형기타학술지Pediatric blood & cancer
https://pubmed.ncbi.nlm.nih.gov/42135985/문헌 12rivaroxabanICSR 검토우선순위 중간
Fondaparinux to treat cerebral venous sinus thrombosis complicated by heparin-induced thrombocytopenia during puerperium: A case report and literature review.
Cerebral venous sinus thrombosis (CVST) occurring during the puerperium is a rare yet life-threatening condition. The management of CVST becomes more complex when complicated by heparin-induced thrombocytopenia (HIT), a prothrombotic adverse effect of heparin therapy. A case of puerperium-associate…
PMID42112699DOI10.5414/CP204953연구 유형기타학술지International journal of clinical pharmacology and therapeutics
https://pubmed.ncbi.nlm.nih.gov/42112699/문헌 13rivaroxabanICSR 검토우선순위 중간
Andexanet alfa Reduces Hematoma Expansion Following Controlled Cortical Impact in Mice Pretreated with Rivaroxaban.
With the introduction of andexanet alfa, a specific antidote is now available to address life-threatening bleeding associated with factor Xa inhibitors. In this study, we explore its use in an experimental model of traumatic brain injury (TBI), mimicking a closed head trauma under rivaroxaban-induc…
PMID41776019DOI10.1007/s12028-026-02463-w연구 유형기타학술지Neurocritical care
https://pubmed.ncbi.nlm.nih.gov/41776019/문헌 14rivaroxaban근거 검토우선순위 낮음
Temporal trends in the prescription of low-dose antithrombotic and anti-inflammatory therapies in Germany (2022-2024).
This study aimed to investigate the prescription rates of low-dose antithrombotic and anti-inflammatory therapies in Germany from 2022 to 2024. We analyzed national outpatient claims data from the German Institute for Drug Use Evaluation. Claims data for patients receiving the following medications…
PMID41055699DOI10.1007/s00392-025-02761-x연구 유형기타학술지Clinical research in cardiology : official journal of the German Cardiac Society
https://pubmed.ncbi.nlm.nih.gov/41055699/문헌 15rivaroxabanICSR 검토우선순위 중간
Evaluating the Role of Andexanet Alfa in Managing Intracranial Hemorrhage in Patients on Vascular-Dose Rivaroxaban: A Clinical Dilemma.
PubMed에 초록이 제공되지 않았습니다.
PMID40884737DOI10.1007/s10557-025-07772-4연구 유형기타학술지Cardiovascular drugs and therapy
https://pubmed.ncbi.nlm.nih.gov/40884737/문헌 16warfarinICSR 검토우선순위 중간
Cancer-associated left ventricular thrombus with preserved ejection fraction: A multicenter descriptive study.
Left ventricular thrombus (LVT) is usually associated with reduced left ventricular ejection fraction (LVEF), yet malignancy-related hypercoagulability may promote LVT despite preserved systolic function. We performed a retrospective descriptive cohort study across three Mayo Clinic tertiary center…
PMID42471929DOI10.1016/j.ahjo.2026.100835연구 유형기타학술지American heart journal plus : cardiology research and practice
https://pubmed.ncbi.nlm.nih.gov/42471929/문헌 17warfarin근거 검토우선순위 낮음
Population Genomics Insights into Pharmacogenomic Differentiation Between East Asians and Europeans.
Genetic variation contributes substantially to interindividual and interpopulation differences in drug response, yet most pharmacogenomic studies remain biased toward European populations. Here, we systematically assessed pharmacogenomic variation across East Asians (EAS) and Europeans (EUR) using…
PMID42233542DOI10.1002/cpt.70354연구 유형기타학술지Clinical pharmacology and therapeutics
https://pubmed.ncbi.nlm.nih.gov/42233542/문헌 18warfarinICSR 검토우선순위 중간
Direct Oral Anticoagulants Versus Warfarin in Durable Left Ventricular Assist Device Recipients Without Atrial Fibrillation.
Lifelong anticoagulation is essential in durable left ventricular assist device (LVAD) recipients to mitigate thrombotic complications, but the optimal anticoagulant strategy remains undefined. Direct oral anticoagulants offer pharmacological advantages over warfarin, yet large-scale outcomes data…
PMID42208715DOI10.1016/j.amjcard.2026.05.021연구 유형기타학술지The American journal of cardiology
https://pubmed.ncbi.nlm.nih.gov/42208715/문헌 19warfarinICSR 검토우선순위 중간
Assessing Natural Health Product-Drug Interactions and Coding Feasibility: Analysis of a New Zealand General Population Dataset from an Online Market Research Panel.
Natural health products (NHPs) include complementary/alternative medicines, dietary supplements, nutraceuticals, and traditional medicines. Natural health products are often self-prescribed and used alongside conventional medicines, raising safety concerns. This study aims to explore NHP-convention…
PMID42105017DOI10.1007/s40264-026-01667-5연구 유형기타학술지Drug safety
https://pubmed.ncbi.nlm.nih.gov/42105017/문헌 20warfarinICSR 검토우선순위 중간
Performance of large language models and clinical decision support in perioperative management of oral anticoagulants.
Perioperative anticoagulant management is critical because of the competing risks of ischemia and bleeding. Large language models (LLMs) and clinical decision support (CDS) have shown substantial advances and are increasingly being applied across various domains of cardiology. However, to date, no…
PMID42070385DOI10.1016/j.ijmedinf.2026.106456연구 유형기타학술지International journal of medical informatics
https://pubmed.ncbi.nlm.nih.gov/42070385/문헌 21warfarin근거 검토우선순위 낮음
Anticoagulation therapy and dementia in atrial fibrillation: An umbrella review of systematic reviews.
Atrial fibrillation (AF) increases the risk of stroke and cognitive decline. While anticoagulation with vitamin K antagonists (VKAs) and direct oral anticoagulants (DOACs) prevents stroke, their role in reducing dementia risk in patients with AF remains unclear. To evaluate the effect of anticoagul…
PMID41564909DOI10.1016/j.tcm.2026.01.003연구 유형기타학술지Trends in cardiovascular medicine
https://pubmed.ncbi.nlm.nih.gov/41564909/문헌 22tirzepatide근거 검토우선순위 낮음
Personalization of incretin therapy: can GLP-1 and GIP receptor polymorphisms influence therapy response?
Incretin-based therapies-glucagon-like peptide-1 receptor agonists (GLP-1RAs) such as semaglutide and the dual GLP-1/GIP receptor agonist tirzepatide-have transformed the management of type 2 diabetes (T2D) and obesity. However, substantial interindividual variability in therapeutic response remain…
PMID42487666DOI10.1210/jendso/bvag149연구 유형기타학술지Journal of the Endocrine Society
https://pubmed.ncbi.nlm.nih.gov/42487666/문헌 23semaglutide근거 검토우선순위 낮음
Therapeutic Benefit or Ocular Risk? Semaglutide and Non-Arteritic Anterior Ischemic Optic Neuropathy: Retraction.
PubMed에 초록이 제공되지 않았습니다.
PMID42468029DOI10.1097/IAE.0000000000004884연구 유형기타학술지Retina (Philadelphia, Pa.)
https://pubmed.ncbi.nlm.nih.gov/42468029/문헌 24semaglutide근거 검토우선순위 낮음
Correction to 'Focus on Semaglutide 2.4 mg/week for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis'.
PubMed에 초록이 제공되지 않았습니다.
PMID42446260DOI10.1111/liv.70790연구 유형기타학술지Liver international : official journal of the International Association for the Study of the Liver
https://pubmed.ncbi.nlm.nih.gov/42446260/문헌 25semaglutide근거 검토우선순위 낮음
Correction to: "Atypical retrobulbar optic neuropathy after semaglutide escalation".
[This corrects the article DOI: 10.1210/jcemcr/luag108.].
PMID42440707DOI10.1210/jcemcr/luag179연구 유형기타학술지JCEM case reports
https://pubmed.ncbi.nlm.nih.gov/42440707/문헌 26semaglutide근거 검토우선순위 낮음
Lifetime cost-effectiveness of semaglutide for secondary prevention in atherosclerotic cardiovascular disease: A select-based simulation study.
PubMed에 초록이 제공되지 않았습니다.
PMID42395069DOI10.1016/j.ajpc.2026.101543연구 유형기타학술지American journal of preventive cardiology
https://pubmed.ncbi.nlm.nih.gov/42395069/문헌 27semaglutideICSR 검토우선순위 중간
GLP-1 receptor agonists in pediatric obesity and diabetes: a systematic review of efficacy, metabolic effects, and safety.
Childhood obesity and youth-onset type 2 diabetes mellitus (T2DM) are increasing, highlighting the need for effective treatments beyond lifestyle intervention and metformin. This review systematically evaluated the efficacy and safety of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in chil…
PMID42365860DOI10.1016/j.diabres.2026.113400연구 유형기타학술지Diabetes research and clinical practice
https://pubmed.ncbi.nlm.nih.gov/42365860/문헌 28semaglutide근거 검토우선순위 낮음
Chronic semaglutide alters ingestive behavior without impairing taste function in mice.
Glucagon-like peptide-1 receptor (GLP-1R) agonists such as semaglutide are highly effective treatments for obesity, yet the mechanisms by which they reduce food intake remain incompletely understood. Because taste plays a critical role in guiding food intake, several clinical studies have investiga…
PMID42364710DOI10.1016/j.molmet.2026.102410연구 유형기타학술지Molecular metabolism
https://pubmed.ncbi.nlm.nih.gov/42364710/문헌 29semaglutideICSR 검토우선순위 중간
Semaglutide and major adverse cardiovascular events in patients with and without DM: A systematic review and meta-analysis.
Semaglutide, a once-weekly glucagon-like peptide-1 receptor agonist (GLP-1 RA), has been associated with cardiovascular benefits, whereas the consistency of its effect across various clinical settings, as well as its safety-economic profile, remains uncertain. MEDLINE, Embase, Cochrane Central Regi…
PMID42339050DOI10.3892/br.2026.2165연구 유형기타학술지Biomedical reports
https://pubmed.ncbi.nlm.nih.gov/42339050/문헌 30tirzepatide근거 검토우선순위 낮음
1-year outcomes of semaglutide, tirzepatide, and sleeve gastrectomy in obesity in type 2 diabetes: a retrospective cohort study.
Type 2 diabetes and obesity are prevalent, inter-related conditions for which treatment options have expanded substantially, yet direct real-world comparisons of modern pharmacological and surgical interventions remain scarce. We aimed to compare 1-year weight loss, glycaemic outcomes, and selected…
PMID42309121DOI10.1016/S2213-8587(26)00030-6연구 유형기타학술지The lancet. Diabetes & endocrinology
https://pubmed.ncbi.nlm.nih.gov/42309121/문헌 31semaglutide근거 검토우선순위 낮음
Weight-Lowering Drugs and Natural Female Fertility-A Systematic Review and Meta-Analysis.
Overweight and obesity are global health concerns linked to impaired female fertility. Weight-lowering drugs are an alternative for achieving weight loss; however, their effect on natural female fertility is unclear. A systematic review and meta-analysis were conducted to summarise the literature o…
PMID42307450DOI10.1111/cob.70092연구 유형기타학술지Clinical obesity
https://pubmed.ncbi.nlm.nih.gov/42307450/문헌 32semaglutide근거 검토우선순위 낮음
Comparative Effectiveness and Safety of Once-Weekly Injectable Semaglutide Versus Dulaglutide in Individuals with Type 2 Diabetes Managed in UK Primary Care: A Population-Based Cohort Study.
The SUSTAIN-7 trial demonstrated greater HbA1c and bodyweight reductions with once-weekly semaglutide versus dulaglutide in type 2 diabetes, but strict eligibility criteria limit external validity. We evaluated the comparative real-world effectiveness and safety of these agents in UK primary care.…
PMID42294355DOI10.1016/j.lanepe.2026.101738연구 유형기타학술지The Lancet regional health. Europe
https://pubmed.ncbi.nlm.nih.gov/42294355/문헌 33semaglutideICSR 검토우선순위 중간
Evidence-informed guidance for the clinical use of oral semaglutide in obesity management.
Oral semaglutide, the first oral glucagon-like peptide-1 (GLP-1) receptor agonist therapy approved for the treatment of type 2 diabetes, is now approved for obesity management and cardiovascular risk reduction in adults, demonstrating weight loss comparable to that of subcutaneous GLP-1 therapies,…
PMID42286992DOI10.1080/00325481.2026.2686467연구 유형기타학술지Postgraduate medicine
https://pubmed.ncbi.nlm.nih.gov/42286992/문헌 34tirzepatide근거 검토우선순위 낮음
GLP-1 receptor agonist adjunct therapy stabilises Ramadan dysglycaemia in insulin-treated diabetes: a CGM-based study.
Patients with type 1 and insulin-treated type 2 diabetes are at higher risk of hypo- and hyperglycaemia during Ramadan fasting. The role of incretin-based add-on therapy (GLP-1 receptor agonist semaglutide and the GLP-1/GIP dual agonist tirzepatide) in attenuating Ramadan dysglycaemia in insulin-tr…
PMID42269776DOI10.1016/j.diabres.2026.113369연구 유형기타학술지Diabetes research and clinical practice
https://pubmed.ncbi.nlm.nih.gov/42269776/문헌 35tirzepatideICSR 검토우선순위 중간
Optic Ischaemic Neuropathy in Incretin-Based Therapy: A Comparative Analysis of Real-World Safety Data.
Non-arteritic anterior ischemic optic neuropathy (NAION) has emerged as a safety concern with semaglutide, prompting formal regulatory review and action by the European Medicines Agency. However, its occurrence across the broader class of incretin-based therapies is insufficiently characterised. Th…
PMID42259643DOI10.1111/dom.70952연구 유형기타학술지Diabetes, obesity & metabolism
https://pubmed.ncbi.nlm.nih.gov/42259643/문헌 36semaglutide근거 검토우선순위 낮음
Risk of Age-Related Ocular Diseases in Non-Diabetic Adults With Obesity Using Glucagon-Like Peptide 1 Receptor Agonists.
To assess whether glucagon-like peptide-1 receptor agonists (GLP-1RAs) are associated with a lower incidence of age-related ocular diseases in non-diabetic older adults with overweight or obesity. We conducted a retrospective, propensity score-matched cohort study using the TriNetX global research…
PMID42259622DOI10.1111/dom.70975연구 유형기타학술지Diabetes, obesity & metabolism
https://pubmed.ncbi.nlm.nih.gov/42259622/문헌 37semaglutideICSR 검토우선순위 중간
Prolonged Dysesthesia After Massive Accidental Semaglutide Overdose: A Case Report.
The use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) has expanded rapidly worldwide for the treatment of obesity, accompanied by a parallel increase in medication errors and accidental overdoses. Gastrointestinal symptoms are the most commonly reported adverse effects in cases of suprat…
PMID42256775DOI10.1016/j.acepjo.2026.100427연구 유형기타학술지Journal of the American College of Emergency Physicians open
https://pubmed.ncbi.nlm.nih.gov/42256775/문헌 38semaglutideICSR 검토우선순위 중간
Efficacy and safety of once-weekly cagrilintide-semaglutide (CagriSema) in adults with type 2 diabetes inadequately controlled on diet and exercise (REIMAGINE 1): a randomised, double-blind, placebo-controlled, phase 3a study.
Cagrilintide-semaglutide (CagriSema) is a novel, once-weekly combination of the amylin receptor agonist cagrilintide and the GLP-1 receptor agonist semaglutide. We aimed to assess the efficacy and safety of cagrilintide-semaglutide for people with type 2 diabetes inadequately controlled with diet a…
PMID42251860DOI10.1016/S2213-8587(26)00126-9연구 유형기타학술지The lancet. Diabetes & endocrinology
https://pubmed.ncbi.nlm.nih.gov/42251860/문헌 39semaglutideICSR 검토우선순위 중간
Cagrilintide-semaglutide (CagriSema) versus semaglutide or cagrilintide in people with type 2 diabetes (REIMAGINE 2): a double-blind, randomised, controlled, phase 3 study.
The amylin receptor agonist cagrilintide and the GLP-1 receptor agonist semaglutide have complementary effects on glycaemic control and bodyweight. We aimed to investigate the efficacy and safety of a fixed-dose combination of cagrilintide and semaglutide (cagrilintide-semaglutide; known as CagriSe…
PMID42251859DOI10.1016/S2213-8587(26)00125-7연구 유형기타학술지The lancet. Diabetes & endocrinology
https://pubmed.ncbi.nlm.nih.gov/42251859/문헌 40semaglutide근거 검토우선순위 낮음
Cagrilintide-semaglutide: a new option for patients with type 2 diabetes.
PubMed에 초록이 제공되지 않았습니다.
PMID42251858DOI10.1016/S2213-8587(26)00129-4연구 유형기타학술지The lancet. Diabetes & endocrinology
https://pubmed.ncbi.nlm.nih.gov/42251858/문헌 41tirzepatide근거 검토우선순위 낮음
Rates of, Reasons for, and Reactions to Discontinuation of GLP-1 Receptor Agonists: A Narrative Review.
GLP-1RAs are increasingly used for their glucose-lowering and weight-management effects, but many patients discontinue them. In this narrative review we aim to review real-world, quantitative and qualitative GLP-1RA discontinuation, adherence, and persistence evidence as it aligns with an establish…
PMID42244474DOI10.1111/dom.70913연구 유형기타학술지Diabetes, obesity & metabolism
https://pubmed.ncbi.nlm.nih.gov/42244474/문헌 42tirzepatideICSR 검토우선순위 중간
Papular granuloma annulare associated with tirzepatide: A case report.
PubMed에 초록이 제공되지 않았습니다.
PMID42499401DOI10.1016/j.jdcr.2026.06.046연구 유형기타학술지JAAD case reports
https://pubmed.ncbi.nlm.nih.gov/42499401/문헌 43tirzepatide근거 검토우선순위 낮음
Impact of incretin therapies on biochemical and imaging outcomes in metabolic dysfunction-associated steatotic liver disease.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver condition. Incretin therapies, including glucagon-like peptide-1 receptor agonists (GLP-1RAs) and emerging dual agonists, have shown promise in improving steatohepatitis. This study aims to evaluate…
PMID42395062DOI10.1016/j.ajpc.2026.101623연구 유형기타학술지American journal of preventive cardiology
https://pubmed.ncbi.nlm.nih.gov/42395062/문헌 44tirzepatide근거 검토우선순위 낮음
Orforglipron for the treatment of moderate-to-severe obstructive sleep apnea in adults with obesity or overweight: Study design and baseline characteristics of ATTAIN-OSA, a phase 3 trial.
Obstructive sleep apnea (OSA) is highly prevalent, yet current treatment remains limited. Poor adherence to positive airway pressure (PAP) and barriers associated with injectable therapies can limit potential therapeutic options for moderate-to-severe OSA. The SURMOUNT-OSA trials demonstrated that…
PMID42383207DOI10.1016/j.conctc.2026.101660연구 유형기타학술지Contemporary clinical trials communications
https://pubmed.ncbi.nlm.nih.gov/42383207/문헌 45tirzepatide근거 검토우선순위 낮음
A trispecific GLP-1/anti-GIPR/FGF21 peptibody exhibits favorable metabolic effects in a diet-induced obesity model.
Metabolic diseases such as obesity and type 2 diabetes are complex disorders involving multiple dysregulated pathways, which may limit the efficacy of single-target therapies. To address this challenge, we developed a trispecific peptibody integrating glucagon-like peptide-1 receptor (GLP-1R) agoni…
PMID42372355DOI10.1016/j.biopha.2026.119717연구 유형기타학술지Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
https://pubmed.ncbi.nlm.nih.gov/42372355/문헌 46tirzepatide근거 검토우선순위 낮음
Tirzepatide, a dual GIP/GLP-1 receptor agonist, attenuates endothelial dysfunction and angiotensin II-induced abdominal aortic aneurysm in ApoE -/- mice.
Endothelial dysfunction is a critical initiating event in abdominal aortic aneurysm (AAA), a condition posing a high risk of a fatal rupture. Dual glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) receptor agonists have emerged as potent treatments for diabetes and…
PMID42342001DOI10.1016/j.phrs.2026.108321연구 유형기타학술지Pharmacological research
https://pubmed.ncbi.nlm.nih.gov/42342001/문헌 47tirzepatideICSR 검토우선순위 중간
Glucagon-Like Peptide-1 Based Therapies and the Risk of Severe Gastrointestinal Motility Adverse Events: A Cohort Study.
Evidence showing the association between glucagon-like 1 (GLP-1) based therapies and severe gastrointestinal motility events is limited and possible treatment effect heterogeneity by demographic and clinical characteristics is unknown. We aimed to compare rates of severe motility-related gastrointe…
PMID42244136DOI10.1111/dom.70963연구 유형기타학술지Diabetes, obesity & metabolism
https://pubmed.ncbi.nlm.nih.gov/42244136/문헌 48tirzepatide근거 검토우선순위 낮음
Short-Term Combined Treatment With Tirzepatide and Metformin for Overweight/Obese Chinese Women With Polycystic Ovary Syndrome: A Prospective, Open-Label, Randomised Controlled Trial.
This study aimed to assess the effects of low-dose tirzepatide combined with metformin (COM) versus metformin (MET) monotherapy in overweight/obese women with polycystic ovary syndrome (PCOS). Sixty overweight/obese women with PCOS were randomised to the MET group (1000 mg twice daily [BID]) or the…
PMID42236268DOI10.1111/dom.70966연구 유형기타학술지Diabetes, obesity & metabolism
https://pubmed.ncbi.nlm.nih.gov/42236268/문헌 49tirzepatide근거 검토우선순위 낮음
Weight Loss Medications in Youth: Decision-Making Experiences, Eating Behaviors, and Uncertainty About Endpoint.
To examine decision-making and experiences with use of weight loss medications by adolescents and young adults (AYAs) with obesity. Participants included AYA 12-22 years old with obesity who were considering starting (PRE) or were using weight loss medications (POST), including semaglutide, liraglu…
PMID42233931DOI10.1016/j.jadohealth.2026.03.017연구 유형기타학술지The Journal of adolescent health : official publication of the Society for Adolescent Medicine
https://pubmed.ncbi.nlm.nih.gov/42233931/문헌 50tirzepatide근거 검토우선순위 낮음
Beyond weight loss: How metabolism in human adipocytes is shaped by GLP-1R agonists and dual GIPR/GLP-1R agonists.
Obesity is a chronic disease leading to multiple comorbidities, including type 2 diabetes mellitus (T2DM), cardiovascular disease, and several cancers. Its prevalence has dramatically risen worldwide, making it a major global concern. Although lifestyle interventions remain the cornerstone of manag…
PMID42229677DOI10.1016/j.phrs.2026.108278연구 유형기타학술지Pharmacological research
https://pubmed.ncbi.nlm.nih.gov/42229677/문헌 51tirzepatideICSR 검토우선순위 중간
The Impact of GLP-1-Based Therapies on Cardiovascular Outcomes in Type 2 Diabetes: A Comprehensive Systematic Review and Network Meta-Analysis.
To provide updated agent-level comparative estimates of GLP-1-based therapies for cardiovascular outcomes in adults with Type 2 diabetes mellitus (T2DM) using a hazard ratio (HR)-based systematic review and network meta-analysis (NMA). PubMed, Cochrane Library and Scopus were searched through Decem…
PMID42219271DOI10.1111/dom.70915연구 유형기타학술지Diabetes, obesity & metabolism
https://pubmed.ncbi.nlm.nih.gov/42219271/문헌 52tirzepatideICSR 검토우선순위 중간
GIP in Cardiovascular and Kidney Disease: From Physiology to Pharmacology.
To provide a comprehensive overview of the cardiovascular and renal effects of glucose-dependent insulinotropic polypeptide (GIP) by integrating its physiological role with recent human trial data on tirzepatide, the first dual GIP and glucagon-like peptide-1 (GLP-1) receptor agonist. This narrativ…
PMID42209267DOI10.1111/dom.70888연구 유형기타학술지Diabetes, obesity & metabolism
https://pubmed.ncbi.nlm.nih.gov/42209267/문헌 53tirzepatide근거 검토우선순위 낮음
Weight Management With Semaglutide and Tirzepatide in U.S. Adults: Projected Impact on Obesity Prevalence and Heart Failure Risk.
PubMed에 초록이 제공되지 않았습니다.
PMID42209262DOI10.1111/dom.70903연구 유형기타학술지Diabetes, obesity & metabolism
https://pubmed.ncbi.nlm.nih.gov/42209262/문헌 54tirzepatide근거 검토우선순위 낮음
Comparative Effects of Individual Glucagon-Like Peptide-1 Receptor Agonist-Based Medications on Direct Measurement of Body Composition Among Adults With Overweight or Obesity With or Without Type 2 Diabetes: A Systematic Review and Network Meta-Analysis of Randomised Controlled Trials.
To compare the effects of individual glucagon-like peptide-1 receptor agonists (GLP-1RAs) on direct body composition among adults with overweight or obesity, with or without type 2 diabetes (T2D). We systematically searched six electronic databases and grey literature from inception to 3 November 2…
PMID42209204DOI10.1111/dom.70884연구 유형기타학술지Diabetes, obesity & metabolism
https://pubmed.ncbi.nlm.nih.gov/42209204/문헌 55tirzepatide근거 검토우선순위 낮음
Beyond weight loss: multisystem benefits of obesity medications.
Obesity is increasingly managed with medications as disease-modifying therapies, reflecting its role as a gateway disease driving metabolic, cardiovascular, reproductive, neuropsychiatric, and mechanical conditions. This Review synthesises evidence from randomised controlled trials and high-quality…
PMID42208956DOI10.1016/S2213-8587(26)00100-2연구 유형기타학술지The lancet. Diabetes & endocrinology
https://pubmed.ncbi.nlm.nih.gov/42208956/문헌 56tirzepatide근거 검토우선순위 낮음
Tirzepatide Versus Semaglutide and Cardiovascular Outcomes in Type 2 Diabetes With Established Cardiovascular Disease: An Indirect Treatment Comparison Meta-Analysis.
PubMed에 초록이 제공되지 않았습니다.
PMID42115707DOI10.1111/dom.70859연구 유형기타학술지Diabetes, obesity & metabolism
https://pubmed.ncbi.nlm.nih.gov/42115707/문헌 57tofacitinib근거 검토우선순위 낮음
Inhibition of Janus kinase/signal transducer and activator of transcription reduces nociceptive sensitization in a murine model of complex regional pain syndrome.
Complex regional pain syndrome (CRPS) is a disabling condition relying in part on the production of pain-supporting autoantibodies. The Janus kinase/signal transducer and activator of transcription (JAK-STAT) signaling system regulates the adaptive system of immunity and is targeted to control auto…
PMID42444784DOI10.1097/PR9.0000000000001475연구 유형기타학술지Pain reports
https://pubmed.ncbi.nlm.nih.gov/42444784/문헌 58tofacitinibICSR 검토우선순위 중간
Tofacitinib exposure across 2 pregnancies in alopecia universalis: Case report and literature review of Janus kinase inhibitors in pregnancy.
PubMed에 초록이 제공되지 않았습니다.
PMID42436912DOI10.1016/j.jdcr.2026.05.069연구 유형기타학술지JAAD case reports
https://pubmed.ncbi.nlm.nih.gov/42436912/문헌 59tofacitinib근거 검토우선순위 낮음
JAK-STAT3-MYC axis defines pathogenic stem cell-like memory CD4 + T cells in rheumatoid arthritis.
Stem cell-like memory T (Tscm) cells are long-lived, self-renewing T cells that sustain chronic immune activation. We analyzed Tscm cells from 11 rheumatoid arthritis (RA) patients and 8 healthy controls using single-cell RNA sequencing and proteomics, comparing csDMARD-treated, tofacitinib-treated…
PMID42309459DOI10.1016/j.clim.2026.110733연구 유형기타학술지Clinical immunology (Orlando, Fla.)
https://pubmed.ncbi.nlm.nih.gov/42309459/문헌 60tofacitinib근거 검토우선순위 낮음
Restoration of Treg function and polarization of M2 macrophages by tofacitinib to alleviate sarcoidosis through the mediation of the JAK3/STAT5 pathway.
Sarcoidosis is a multisystem granulomatous syndrome with a wide range of clinical features. Tofacitinib, a JAK inhibitor, may become a new treatment for sarcoidosis. The study aimed to elucidate how tofacitinib modulates immune responses and reduces granuloma formation in SodA-induced sarcoidosis.…
PMID42251788DOI10.1016/j.molimm.2026.05.013연구 유형기타학술지Molecular immunology
https://pubmed.ncbi.nlm.nih.gov/42251788/문헌 61tofacitinib근거 검토우선순위 낮음
Emerging topical nonsteroidal therapies in pediatric dermatology: atopic dermatitis, psoriasis, alopecia areata, vitiligo, and seborrheic dermatitis.
To review the current literature for updates on pediatric nonsteroidal topical therapies (NSTT) for the treatment of atopic dermatitis (AD), psoriasis, alopecia areata (AA), vitiligo, and seborrheic dermatitis (SD). The FDA approved difamilast and expanded the approved age ranges for roflumilast, t…
PMID42240630DOI10.1097/MOP.0000000000001580연구 유형기타학술지Current opinion in pediatrics
https://pubmed.ncbi.nlm.nih.gov/42240630/문헌 62tofacitinib근거 검토우선순위 낮음
Real-world efficacy and safety of tofacitinib on the progression of skin sclerosis in patients with systemic sclerosis: An analysis of national multicenter data from the Chinese Rheumatism Data Center.
PubMed에 초록이 제공되지 않았습니다.
PMID41966277DOI10.1016/j.jaad.2026.03.102연구 유형기타학술지Journal of the American Academy of Dermatology
https://pubmed.ncbi.nlm.nih.gov/41966277/문헌 63tofacitinibICSR 검토우선순위 중간
Sequential small-molecule therapy for lymphocytic cicatricial alopecia: A multicenter prospective cohort pilot study.
Lymphocytic cicatricial alopecia (LCA) is a rare disorder causing irreversible hair follicle stem cell damage, with limited evidence supporting systemic treatments. To assess the efficacy and safety of a predefined three-stage sequential small-molecule therapy for active LCA. This multicenter prosp…
PMID41812983DOI10.1016/j.jaad.2026.03.011연구 유형기타학술지Journal of the American Academy of Dermatology
https://pubmed.ncbi.nlm.nih.gov/41812983/문헌 64tofacitinibICSR 검토우선순위 중간
Effectiveness and Safety of Janus Kinase Inhibitors in Acute Severe Ulcerative Colitis: A Systematic Review and Meta-Analysis.
Janus kinase (JAK) inhibitors have been reported to be useful in acute severe ulcerative colitis (ASUC). We performed a systematic review and meta-analysis to assess their effectiveness and safety in ASUC. Electronic databases (PubMed, Embase, and Scopus) were searched on December 17, 2025, to iden…
PMID41690364DOI10.1016/j.cgh.2026.02.006연구 유형기타학술지Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
https://pubmed.ncbi.nlm.nih.gov/41690364/문헌 65tofacitinibICSR 검토우선순위 중간
Novel Use of a Topical JAK/STAT Inhibitor in the Management of Refractory Erythromelalgia: A Case Report.
PubMed에 초록이 제공되지 않았습니다.
PMID41609563DOI10.1111/ijd.70313연구 유형기타학술지International journal of dermatology
https://pubmed.ncbi.nlm.nih.gov/41609563/문헌 66tofacitinib근거 검토우선순위 낮음
Deciphering in vitro-in vivo correlation of single-dose injectable sustained-release tofacitinib-loaded microspheres for long-acting anti-inflammatory therapy of rheumatoid arthritis.
Tofacitinib is a potent Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA); however, its clinical application is limited by inherent side effects, a short half-life, and the requirement for frequent dosing. In this study, poly(lactic-co-glycolic acid) (PLGA)-based injectable sust…
PMID42508508DOI10.1016/j.ijpharm.2026.127239연구 유형기타학술지International journal of pharmaceutics
https://pubmed.ncbi.nlm.nih.gov/42508508/문헌 67valproateICSR 검토우선순위 중간
Successful Treatment of Rapid Cycling Bipolar Disorder With Lurasidone, Clozapine, and Valproate: A Case Report.
PubMed에 초록이 제공되지 않았습니다.
PMID42464586DOI10.1111/bdi.70155연구 유형기타학술지Bipolar disorders
https://pubmed.ncbi.nlm.nih.gov/42464586/문헌 68valproate근거 검토우선순위 낮음
Abscisic Acid Enhances Hippocampal Neuroplasticity and Rescues Learning and Memory Deficits in a Valproate-Induced Rat Model of Autism.
This study investigated the possible protective effects of abscisic acid (ABA), a naturally occurring phytohormone with incipient neuromodulatory properties, to alleviate cognitive and neurological alterations in a valproate (VPA)-induced rat model of autism. ABA was injected intra-CA1 hippocampal…
PMID42413917DOI10.1002/jdn.70156연구 유형기타학술지International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
https://pubmed.ncbi.nlm.nih.gov/42413917/문헌 69valproate근거 검토우선순위 낮음
Simultaneous Determination of Levetiracetam, Sodium Valproate, and Olanzapine in Human Plasma by UPLC-MS/MS for Therapeutic Drug Monitoring.
Levetiracetam, sodium valproate, and olanzapine are widely used for epilepsy, but their therapeutic windows and pharmacokinetic variability require TDM. No existing method enables their simultaneous quantification. This study aimed to establish and validate a UPLC-MS/MS method for their simultaneou…
PMID42394171DOI10.1002/bmc.70536연구 유형기타학술지Biomedical chromatography : BMC
https://pubmed.ncbi.nlm.nih.gov/42394171/문헌 70valproate근거 검토우선순위 낮음
Analysis of Content Characteristics of Partial Biochemical Substances in Peripheral Blood of Autism Spectrum Disorder Model Rats at Different Weeks of Age.
To observe the content characteristics and variation rules of partial biochemical substances in peripheral blood of autism model rats at different weeks of age. This was an experimental study. Time-mated female Sprague-Dawley (SD) rats were given a single intraperitoneal injection of 600 mg/kg valp…
PMID42332381DOI10.1002/jdn.70144연구 유형기타학술지International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
https://pubmed.ncbi.nlm.nih.gov/42332381/문헌 71valproate근거 검토우선순위 낮음
Genetic analysis of self-limiting familial infantile epilepsy caused by PRRT2 variants in Indian patients.
Self-limiting familial infantile epilepsy (SeLFIE) is an epilepsy syndrome characterized by recurrent focal motor seizures. It follows an autosomal dominant inheritance pattern. Phenotypic and genetic heterogeneity of SeLFIE are associated with the PRRT2 gene, with the most common mutation being th…
PMID42269415DOI10.1016/j.seizure.2026.05.025연구 유형기타학술지Seizure
https://pubmed.ncbi.nlm.nih.gov/42269415/문헌 72valproate근거 검토우선순위 낮음
Functional and morphological alterations in animal models of valproic acid exposure.
Valproic acid (VPA) is an antiepileptic and mood-stabilizing drug; however, it also produces side effects. This review examines how VPA exposure influences neurodevelopment, endocrine regulation, reproduction, and sex-dependent outcomes, providing an integrated interpretation of its biological cons…
PMID42176764DOI10.1016/j.neubiorev.2026.106772연구 유형기타학술지Neuroscience and biobehavioral reviews
https://pubmed.ncbi.nlm.nih.gov/42176764/문헌 73valproate근거 검토우선순위 낮음
Prolonged ambulatory EEG findings and risk of seizure recurrence in adults with generalized tonic-clonic seizures alone: A multicentre study.
Epilepsy with generalized tonic-clonic seizures alone (GTCA) is a distinct subtype of idiopathic generalized epilepsy (IGE), yet its prognostic markers remain poorly defined. This study aimed to evaluate whether prolonged ambulatory EEG (paEEG), when integrated with clinical variables, improves the…
PMID42019261DOI10.1016/j.yebeh.2026.111064연구 유형기타학술지Epilepsy & behavior : E&B
https://pubmed.ncbi.nlm.nih.gov/42019261/문헌 74valproate근거 검토우선순위 낮음
Impact of antiseizure medications on thyroid function in persons with epilepsy.
Antiseizure medications (ASMs) are central to epilepsy management but may disrupt endocrine function, particularly thyroid homeostasis. Subclinical and central hypothyroidism are increasingly recognized among ASM users, yet routine thyroid monitoring remains uncommon. To evaluate the prevalence and…
PMID42019260DOI10.1016/j.yebeh.2026.111058연구 유형기타학술지Epilepsy & behavior : E&B
https://pubmed.ncbi.nlm.nih.gov/42019260/문헌 75valproate근거 검토우선순위 낮음
Reduced NR2F6 expression reshapes the VPA-induced transcriptome in human hepatocytes and increases lipid accumulation.
Valproic acid (VPA) is an antiepileptic drug associated with hepatic steatosis, yet the transcriptional regulators determining cellular susceptibility to VPA remain incompletely defined. In a time-series RNA-sequencing analysis of primary human liver spheroids, NR2F6 emerged as one of the nuclear r…
PMID41936854DOI10.1016/j.tox.2026.154457연구 유형기타학술지Toxicology
https://pubmed.ncbi.nlm.nih.gov/41936854/문헌 76valproate근거 검토우선순위 낮음
Assessing molecular gene by treatment interactions using a population of neural progenitors exposed to valproic acid and lithium.
Gene by treatment (GxT) interactions likely contribute to variability in clinical response, but are difficult to identify in population studies. Here, we applied psychiatric and neurological disorder treatments to a genotyped population of human neural progenitors (n = 83 donors) and measured molec…
PMID41935183DOI10.1038/s41380-026-03578-4연구 유형기타학술지Molecular psychiatry
https://pubmed.ncbi.nlm.nih.gov/41935183/문헌 77valproate근거 검토우선순위 낮음
Association of SGLT2 inhibitors with suicidality, all-cause mortality, and hospitalization in bipolar disorder: A cohort study of 1.23 million adults.
Sodium-glucose cotransporter-2 inhibitors (SGLT2is) have demonstrated promising neuropsychiatric properties in animal research. We aimed to examine whether SGLT2i exposure is associated with reduced incidence of suicidality, all-cause mortality, and hospitalization in bipolar disorder (BD). This co…
PMID41921881DOI10.1016/j.jad.2026.121702연구 유형기타학술지Journal of affective disorders
https://pubmed.ncbi.nlm.nih.gov/41921881/문헌 78valproate근거 검토우선순위 낮음
Economic Evaluation of Therapeutic Drug Monitoring and Precision Dosing in Pediatrics: A Short Communication.
This scoping review evaluates the economic impact of therapeutic drug monitoring (TDM) and model-informed precision dosing (MIPD), incorporating clinical pharmacokinetics principles in pediatric populations. This study followed the PRISMA-ScR guidelines. From 1057 articles identified, 8 met inclusi…
PMID41408689DOI10.1097/FTD.0000000000001424연구 유형기타학술지Therapeutic drug monitoring
https://pubmed.ncbi.nlm.nih.gov/41408689/문헌 79valproate근거 검토우선순위 낮음
Combined effects of melatonin and valproic acid in cerebral ischemia via modulation of oxidative stress and melatonin receptors.
Ischemic stroke is a major cause of mortality and disability worldwide, with limited effective neuroprotective treatments. Epigenetic modulation and oxidative stress regulation have emerged as promising therapeutic targets. This study aimed to evaluate the neuroprotective effects of melatonin and v…
PMID42517197DOI10.1080/01616412.2026.2711004연구 유형기타학술지Neurological research
https://pubmed.ncbi.nlm.nih.gov/42517197/문헌 80valproateICSR 검토우선순위 중간
Late-onset PSP/FTD-like atypical parkinsonism as a novel phenotype of POLG-related disease: a case report.
POLG-related disease is a multisystem mitochondrial disorder that may mimic primary neurodegenerative syndromes. We report a 70-year-old man with progressive cognitive decline, rigid-akinetic parkinsonism, postural instability, vertical supranuclear gaze palsy, and prominent executive and semantic…
PMID42507247DOI10.1007/s13760-026-03145-2연구 유형기타학술지Acta neurologica Belgica
https://pubmed.ncbi.nlm.nih.gov/42507247/