tofacitinib우선순위 낮음근거 검토기타
LITERATURE DETAIL · PMID 42309459
JAK-STAT3-MYC axis defines pathogenic stem cell-like memory CD4 + T cells in rheumatoid arthritis.
JAK-STAT3-MYC axis defines pathogenic stem cell-like memory CD4 + T cells in rheumatoid arthritis.
- 저자
- Seojin Yang, Miriam Kim, Kyoung-Lin Park, Hyunji Kim, Jun Won Park, Jin Kyun Park
- 저널
- Clinical immunology (Orlando, Fla.)
- 공개일
- 2026 Aug
- 연구 유형
- 기타
- DOI
- 10.1016/j.clim.2026.110733
문헌 요약
Stem cell-like memory T (Tscm) cells are long-lived, self-renewing T cells that sustain chronic immune activation. We analyzed Tscm cells from 11 rheumatoid arthritis (RA) patients and 8 healthy controls using single-cell RNA sequencing and proteomics, comparing csDMARD-treated, tofacitinib-treated, and control groups. RA CD4 + Tscm cells exhibited a dist…
PV 검토 포인트
누적 안전성 근거로 분류하고 기존 시그널과의 일관성을 확인합니다.