valproate우선순위 낮음근거 검토기타
LITERATURE DETAIL · PMID 41935183
Assessing molecular gene by treatment interactions using a population of neural progenitors exposed to valproic acid and lithium.
Assessing molecular gene by treatment interactions using a population of neural progenitors exposed to valproic acid and lithium.
- 저자
- Jordan M Valone, Brandon D Le, Nana Matoba, Jessica T Mory, Justin M Wolter, Michael I Love
- 저널
- Molecular psychiatry
- 공개일
- 2026 Aug
- 연구 유형
- 기타
- DOI
- 10.1038/s41380-026-03578-4
문헌 요약
Gene by treatment (GxT) interactions likely contribute to variability in clinical response, but are difficult to identify in population studies. Here, we applied psychiatric and neurological disorder treatments to a genotyped population of human neural progenitors (n = 83 donors) and measured molecular responses on chromatin accessibility and gene express…
PV 검토 포인트
누적 안전성 근거로 분류하고 기존 시그널과의 일관성을 확인합니다.