tofacitinib우선순위 낮음근거 검토기타
LITERATURE DETAIL · PMID 42508508
Deciphering in vitro-in vivo correlation of single-dose injectable sustained-release tofacitinib-loaded microspheres for long-acting anti-inflammatory therapy of rheumatoid arthritis.
Deciphering in vitro-in vivo correlation of single-dose injectable sustained-release tofacitinib-loaded microspheres for long-acting anti-inflammatory therapy of rheumatoid arthritis.
- 저자
- Xin-Hong Wu, Le-Yan Gu, Ye-Chao Zhang, Jing-Yi Liu, Yan-Kai Qu, Cai-Yi Ping
- 저널
- International journal of pharmaceutics
- 공개일
- 2026 Jul 27
- 연구 유형
- 기타
- DOI
- 10.1016/j.ijpharm.2026.127239
문헌 요약
Tofacitinib is a potent Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA); however, its clinical application is limited by inherent side effects, a short half-life, and the requirement for frequent dosing. In this study, poly(lactic-co-glycolic acid) (PLGA)-based injectable sustained-release tofacitinib microspheres with distinct in vi…
PV 검토 포인트
누적 안전성 근거로 분류하고 기존 시그널과의 일관성을 확인합니다.