valproate우선순위 낮음근거 검토기타
LITERATURE DETAIL · PMID 42176764
Functional and morphological alterations in animal models of valproic acid exposure.
Functional and morphological alterations in animal models of valproic acid exposure.
- 저자
- José Luis Encarnación-Sánchez, Oscar González-Flores, Marcos García-Juárez, Carlos Edmundo Aguilar-Pérez, Cesar Javik Dorantes Barrios, José Luis Tlachi-López
- 저널
- Neuroscience and biobehavioral reviews
- 공개일
- 2026 Aug
- 연구 유형
- 기타
- DOI
- 10.1016/j.neubiorev.2026.106772
문헌 요약
Valproic acid (VPA) is an antiepileptic and mood-stabilizing drug; however, it also produces side effects. This review examines how VPA exposure influences neurodevelopment, endocrine regulation, reproduction, and sex-dependent outcomes, providing an integrated interpretation of its biological consequences. VPA modifies chromatin structure, gene expressio…
PV 검토 포인트
누적 안전성 근거로 분류하고 기존 시그널과의 일관성을 확인합니다.