tofacitinib우선순위 낮음근거 검토기타
LITERATURE DETAIL · PMID 42251788
Restoration of Treg function and polarization of M2 macrophages by tofacitinib to alleviate sarcoidosis through the mediation of the JAK3/STAT5 pathway.
Restoration of Treg function and polarization of M2 macrophages by tofacitinib to alleviate sarcoidosis through the mediation of the JAK3/STAT5 pathway.
- 저자
- Ting Sheng, Shiyun Zhang, Di Ma, Yiyang Jie, Yong Wang, Jingjing Ding
- 저널
- Molecular immunology
- 공개일
- 2026 Aug
- 연구 유형
- 기타
- DOI
- 10.1016/j.molimm.2026.05.013
문헌 요약
Sarcoidosis is a multisystem granulomatous syndrome with a wide range of clinical features. Tofacitinib, a JAK inhibitor, may become a new treatment for sarcoidosis. The study aimed to elucidate how tofacitinib modulates immune responses and reduces granuloma formation in SodA-induced sarcoidosis. To evaluate the effects of tofacitinib on granuloma format…
PV 검토 포인트
누적 안전성 근거로 분류하고 기존 시그널과의 일관성을 확인합니다.