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LITERATURE DETAIL · PMID 42438486

A first-in-human study evaluating safety, PK, and PD of a novel universal anticoagulant reversal agent, OKL-1111.

A first-in-human study evaluating safety, PK, and PD of a novel universal anticoagulant reversal agent, OKL-1111.

저자
Edwin Spaans, Denisa Wilkes, Maxime Schreurs, Julien Beyrath, Jules A A C Heuberger, Alex Zwiers
저널
Blood vessels, thrombosis & hemostasis
공개일
2026 Aug
연구 유형
기타
DOI
10.1016/j.bvth.2026.100176

문헌 요약

OKL-1111 is a small-molecule γ-cyclodextrin universal reversal agent for anticoagulants and platelet inhibitors that was being developed to significantly shorten time to treatment for intracerebral hemorrhage. Part A of this single-center, randomized, placebo-controlled, double-blind, single-ascending-dose, alternating-group, partial crossover trial evalu…

PV 검토 포인트

개별 증례 가능성과 중대성, 예상성 및 중복 여부를 우선 검토합니다.

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