valproate우선순위 낮음근거 검토기타
LITERATURE DETAIL · PMID 41936854
Reduced NR2F6 expression reshapes the VPA-induced transcriptome in human hepatocytes and increases lipid accumulation.
Reduced NR2F6 expression reshapes the VPA-induced transcriptome in human hepatocytes and increases lipid accumulation.
- 저자
- Kaidi Guo, Marcha Verheijen, Marcel van Herwijnen, Florian Caiment, Twan van den Beucken
- 저널
- Toxicology
- 공개일
- 2026 Aug
- 연구 유형
- 기타
- DOI
- 10.1016/j.tox.2026.154457
문헌 요약
Valproic acid (VPA) is an antiepileptic drug associated with hepatic steatosis, yet the transcriptional regulators determining cellular susceptibility to VPA remain incompletely defined. In a time-series RNA-sequencing analysis of primary human liver spheroids, NR2F6 emerged as one of the nuclear regulators predicted to shape the hepatocellular response t…
PV 검토 포인트
누적 안전성 근거로 분류하고 기존 시그널과의 일관성을 확인합니다.