valproate우선순위 낮음근거 검토기타
LITERATURE DETAIL · PMID 42624452
Intergenerational Consequences of Valproic Acid Exposure: Dose- and Sex-Specific Effects in Drosophila melanogaster.
Intergenerational Consequences of Valproic Acid Exposure: Dose- and Sex-Specific Effects in Drosophila melanogaster.
- 저자
- Silvana Hof-Michel, Belén Olga Ferrando Hernandez, Andreas Vilcinskas, Anika E Wagner
- 저널
- European journal of pharmacology
- 공개일
- 2026 Aug 20
- 연구 유형
- 기타
- DOI
- 10.1016/j.ejphar.2026.179271
문헌 요약
Valproic acid (VPA) is a widely used anticonvulsant and mood stabilizer, that is notable for its role as histone deacetylase (HDAC) inhibitor and its potential impact on epigenetic modulation. However, its intergenerational impacts are not fully understood. In this study, we investigated the dose- and sex-dependent intergenerational effects of VPA using D…
PV 검토 포인트
누적 안전성 근거로 분류하고 기존 시그널과의 일관성을 확인합니다.