semaglutide우선순위 낮음근거 검토동물시험
LITERATURE DETAIL · PMID 42622904
Semaglutide Alleviates LPS-Induced Cognitive Disorder via O-GlcNAcylation of AKT-mTOR Signaling Pathway Components.
Semaglutide Alleviates LPS-Induced Cognitive Disorder via O-GlcNAcylation of AKT-mTOR Signaling Pathway Components.
- 저자
- Qiangwei Liu, Lu Chen, Mengxue Zhang, Zhun Wang, Xiaokun Wang, Ying Dong
- 저널
- Neuromolecular medicine
- 공개일
- 2026 Aug 20
- 연구 유형
- 동물시험
- DOI
- 10.1007/s12017-026-08945-6
문헌 요약
Perioperative neurocognitive disorder (PND) manifests as neurocognitive alterations induced by anesthesia and surgical stress. High-risk factors, including advanced age, obesity, diabetes, and preoperative neurological dysfunction, accelerate PND progression, with neuroinflammation serving as a core pathological mechanism throughout PND pathogenesis. Sema…
PV 검토 포인트
누적 안전성 근거로 분류하고 기존 시그널과의 일관성을 확인합니다.