문헌 01rivaroxabanICSR 검토우선순위 중간
Hematoma Volume in Apixaban vs. Rivaroxaban-Related Intracerebral Hemorrhage.
Among patients with intracerebral hemorrhage (ICH) associated with direct oral anticoagulant (DOAC) use, it is unknown whether hematoma volume differs according to DOAC agent. The primary objective of our study was to compare baseline hematoma volume between apixaban and rivaroxaban-related ICH. We…
PMID42498894DOI10.1007/s12028-026-02587-z연구 유형기타학술지Neurocritical care
https://pubmed.ncbi.nlm.nih.gov/42498894/문헌 02apixaban근거 검토우선순위 낮음
Nanoparticle Biofunctionalization of Bioprosthetic Heart Valves to Modulate Mechanisms of Structural Valve Deterioration.
Bioprosthetic heart valves made from glutaraldehyde-fixed animal pericardium are widely used for valve replacement but are prone to early degeneration arising from the interplay of thrombosis, inflammation, and calcification. Current chemical treatments passivate the tissue surface but do not addre…
PMID42492292DOI10.1016/j.jacbts.2026.101641연구 유형기타학술지JACC. Basic to translational science
https://pubmed.ncbi.nlm.nih.gov/42492292/문헌 03warfarinICSR 검토우선순위 중간
Real-world comparative safety and effectiveness of rivaroxaban versus warfarin in patients with non-valvular atrial fibrillation: a prospective cohort study.
Direct oral anticoagulants (DOACs) provide several advantages over warfarin for stroke prevention in atrial fibrillation, particularly among patients with unstable or difficult-to-control international normalized ratio (INR) values. To compare the safety and efficacy of rivaroxaban versus warfarin…
PMID42499238DOI10.1080/03007995.2026.2706317연구 유형기타학술지Current medical research and opinion
https://pubmed.ncbi.nlm.nih.gov/42499238/문헌 04rivaroxabanICSR 검토우선순위 중간
Disagreement in rivaroxaban dosing between Cockcroft-Gault and eGFR equations in nonvalvular atrial fibrillation: a statewide analysis.
Rivaroxaban dosing for nonvalvular atrial fibrillation (NVAF) is based on Cockcroft-Gault creatinine clearance using actual body weight (CG-CrCl-ABW) per FDA labeling. Recent recommendations support utilizing the race-free CKD-EPI 2021 equation for estimating kidney function. However, it is unknown…
PMID42493732DOI10.1007/s11239-026-03367-4연구 유형기타학술지Journal of thrombosis and thrombolysis
https://pubmed.ncbi.nlm.nih.gov/42493732/문헌 05rivaroxaban근거 검토우선순위 낮음
Establishing a Rodent Model of Venous Stent Thrombosis and In-Stent Restenosis.
To establish a controlled small-animal model of venous stent placement enabling longitudinal evaluation of thrombosis, vessel wall remodeling, and in-stent restenosis (ISR). Antithrombotic treatment arms were included to assess the model's responsiveness to biologic differences. Forty-four adult Sp…
PMID42492770DOI10.1016/j.jvir.2026.108977연구 유형기타학술지Journal of vascular and interventional radiology : JVIR
https://pubmed.ncbi.nlm.nih.gov/42492770/문헌 06rivaroxabanICSR 검토우선순위 중간
Partial segmental thrombosis of the corpus cavernosum: a case report and review of the literature.
Partial segmental thrombosis of the corpus cavernosum (PSTCC) is a rare urological condition presenting as localized perineal pain and asymmetric corporal swelling. We report a 27-year-old male with subacute penile pain and decreased erectile rigidity following a prolonged erection. The patient had…
PMID42483556DOI10.1093/jscr/rjag598연구 유형기타학술지Journal of surgical case reports
https://pubmed.ncbi.nlm.nih.gov/42483556/문헌 07rivaroxaban근거 검토우선순위 낮음
Automated DNA-Encoded Library Synthesis and Activity-Based Screening at the Attomole Scale.
One-bead-one-compound DNA-encoded library (OBOC-DEL) technology enables synthesis and activity-based screening of diverse compound collections but requires complex microfluidic instrumentation and laborious manual bead handling. Here, we execute DEL synthesis on 2.8-μm-dia magnetic beads and encaps…
PMID42482528DOI10.1021/acs.jmedchem.6c01339연구 유형기타학술지Journal of medicinal chemistry
https://pubmed.ncbi.nlm.nih.gov/42482528/문헌 08edoxaban근거 검토우선순위 낮음
Can edoxaban and rivaroxaban be prescribed for breastfeeding mothers? - The New Horizons Clinical Trial.
The risk of venous thromboembolism is significantly increased during the postnatal period and pharmacological thromboprophylaxis remains the cornerstone of VTE preventive measures. It is well recognised that many women struggle with the parenteral nature of low molecular weight heparin. The aim of…
PMID42480855DOI10.1016/j.jtha.2026.07.010연구 유형기타학술지Journal of thrombosis and haemostasis : JTH
https://pubmed.ncbi.nlm.nih.gov/42480855/문헌 09rivaroxaban근거 검토우선순위 낮음
Impact of parameter settings on the estimation of drug exposure with the individualized dispensing patterns method.
To assess the impact of parameter settings when using the individualized dispensing patterns (IDP) method to estimate exposure duration from dispensing data. We conducted a cohort study using a 2% representative sample of the French healthcare insurance database from 2013 to 2022. The IDP method de…
PMID42478294DOI10.1002/bcp.70701연구 유형기타학술지British journal of clinical pharmacology
https://pubmed.ncbi.nlm.nih.gov/42478294/문헌 10dabigatran근거 검토우선순위 낮음
Screening study of serum thrombosis-related target proteins using a specific dabigatran-functionalized material.
A drug-related protein profiling strategy was developed based on drug-protein interactions, utilizing a magnetic adsorbent modified with dabigatran (Fe 3 O 4 @SiO 2 @DBG). Dabigatran (DBG), the hydrolytic product of dabigatran etexilate, which is a drug for thromboembolic disease treatment, was cov…
PMID42478503DOI10.1039/d6ay01005a연구 유형기타학술지Analytical methods : advancing methods and applications
https://pubmed.ncbi.nlm.nih.gov/42478503/문헌 11warfarinICSR 검토우선순위 중간
Comparative outcomes of direct oral anticoagulants versus warfarin in patients with atrial fibrillation and liver cirrhosis: A propensity score matched TriNetX analysis.
Anticoagulation in patients with atrial fibrillation (AF) and liver cirrhosis is challenging due to competing risks of thrombosis and bleeding. While direct oral anticoagulants (DOACs) have emerged as alternatives to warfarin, their comparative safety and effectiveness in cirrhosis remain incomplet…
PMID42493734DOI10.1007/s11239-026-03359-4연구 유형기타학술지Journal of thrombosis and thrombolysis
https://pubmed.ncbi.nlm.nih.gov/42493734/문헌 12warfarinICSR 검토우선순위 중간
Quality of Anticoagulation in Self versus Standard Management: Assessing the Influence of Education Level on Self-Managed Patient Outcomes.
Self-management of vitamin K antagonist (VKA) therapy may enhance the quality of anticoagulation compared with conventional monitoring; however, selection criteria in low-socioeconomic settings-and the role of education-remain unclear. This study aims to evaluate the effect of education level and s…
PMID42492783DOI10.1016/j.ihj.2026.07.003연구 유형기타학술지Indian heart journal
https://pubmed.ncbi.nlm.nih.gov/42492783/문헌 13warfarinICSR 검토우선순위 중간
Risk and Timing of Intracerebral Hemorrhage Expansion Among Patients Treated with Antithrombotic Agents.
The risk of intracerebral hemorrhage (ICH) hematoma expansion (HE) is highest in the first hours after onset, and coagulopathy is believed to further increase this risk. However, there is a paucity of data comparing the risk of HE over time for various antithrombotic agents. We conducted a retrospe…
PMID42477256DOI10.1007/s12028-026-02581-5연구 유형기타학술지Neurocritical care
https://pubmed.ncbi.nlm.nih.gov/42477256/문헌 14semaglutide근거 검토우선순위 낮음
Comparison of lifestyle, surgery, and semaglutide for weight management in endometrial cancer: a prospective observational study.
To compare sleeve gastrectomy, semaglutide therapy, and the Diet, Exercise, Accompany and Refresh (DEAR) weight management programme for weight control, metabolic improvement, and oncological outcomes in patients with endometrial cancer receiving fertility-sparing treatment. In this prospective obs…
PMID42495930DOI10.1080/01443615.2026.2701996연구 유형기타학술지Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
https://pubmed.ncbi.nlm.nih.gov/42495930/문헌 15semaglutideICSR 검토우선순위 중간
Therapeutic role of semaglutide in metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction-associated steatohepatitis: A systematic review and meta-analysis of placebo-controlled trials with GRADE evidence assessment.
Nonalcoholic fatty liver disease (NAFLD) and its progressive form, nonalcoholic steatohepatitis (NASH), are leading causes of chronic liver disease worldwide. Despite the rising clinical burden, there are currently no approved pharmacologic therapies. Semaglutide, a glucagon-like peptide-1 receptor…
PMID42499082DOI10.1097/MD.0000000000049916연구 유형기타학술지Medicine
https://pubmed.ncbi.nlm.nih.gov/42499082/문헌 16semaglutideICSR 검토우선순위 중간
Effects of glucagon-like peptide-1 receptor agonists on metabolic outcomes in antipsychotic-treated patients with schizophrenia: A systematic review and meta-analysis.
Individuals with schizophrenia have markedly increased cardiometabolic morbidity, largely attributable to antipsychotic-induced weight gain, insulin resistance, and dyslipidemia, particularly with clozapine- and olanzapine-based regimens. This systematic review and meta-analysis evaluated the effic…
PMID42497473DOI10.1016/j.schres.2026.06.025연구 유형기타학술지Schizophrenia research
https://pubmed.ncbi.nlm.nih.gov/42497473/문헌 17semaglutide근거 검토우선순위 낮음
Impact of semaglutide on cognitive function in patients with type 2 diabetes and mild cognitive impairment: a 24-month observational study.
Type 2 diabetes mellitus (T2DM) is associated with an increased risk of mild cognitive impairment (MCI) and dementia. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) provide cardiovascular and metabolic benefits, and emerging data suggest neurocognitive effects. We conducted a 24-month prospe…
PMID42493728DOI10.1007/s11739-026-04468-x연구 유형기타학술지Internal and emergency medicine
https://pubmed.ncbi.nlm.nih.gov/42493728/문헌 18semaglutide근거 검토우선순위 낮음
Semaglutide for prevention of type 2 diabetes in women with postpartum prediabetes after gestational diabetes: protocol for a Belgian multicentre double-blind randomised placebo-controlled trial.
Women with postpartum pre-diabetes following gestational diabetes mellitus (GDM) are at particularly high risk of developing type 2 diabetes mellitus (T2DM). While the implementation of effective lifestyle interventions in the early postpartum period is often difficult and has in general limited ef…
PMID42493207DOI10.1136/bmjopen-2026-118191연구 유형기타학술지BMJ open
https://pubmed.ncbi.nlm.nih.gov/42493207/문헌 19semaglutide근거 검토우선순위 낮음
Advances in proteomics research related to semaglutide: evidence from humans and animals.
With the advancement of proteomics technologies, an increasing number of studies have begun to examine semaglutide-associated protein expression changes and pathway alterations across different biological contexts. However, existing evidence remains fragmented across different disease backgrounds,…
PMID42489869DOI10.1007/s40618-026-02989-y연구 유형기타학술지Journal of endocrinological investigation
https://pubmed.ncbi.nlm.nih.gov/42489869/문헌 20tirzepatideICSR 검토우선순위 중간
Hypersensitivity Reaction to Tirzepatide With Demonstrated Tolerance to Semaglutide: A Case Report.
Hypersensitivity reactions to glucagon-like peptide-1 receptor agonists (GLP-1RAs) are uncommon but clinically significant given their expanding use for obesity and type 2 diabetes. Tirzepatide, a dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) receptor agonist, and reports of allergi…
PMID42487660DOI10.1002/ccr3.73183연구 유형기타학술지Clinical case reports
https://pubmed.ncbi.nlm.nih.gov/42487660/문헌 21semaglutide근거 검토우선순위 낮음
AI digital pathology as a key tool providing in-depth understanding of the progression and regression of MASH and fibrosis in male mouse models.
Optimizing murine models for studying Metabolic Dysfunction-Associated Steatohepatitis (MASH) and fibrosis is crucial for understanding disease mechanisms and evaluating therapies. In this study, we characterized diet-induced male murine models of MASH and liver fibrosis using an AI-digital patholo…
PMID42486853DOI10.1038/s41467-026-73370-z연구 유형기타학술지Nature communications
https://pubmed.ncbi.nlm.nih.gov/42486853/문헌 22semaglutideICSR 검토우선순위 중간
Therapeutic Potential of Incretin-Based Therapies for Alcohol Use Disorder - A narrative review of available clinical evidence.
Alcohol use disorder (AUD) remains a major global health burden, yet pharmacological treatment options are limited, and an urgent need for novel molecular targets for the treatment of AUD exists. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have been used for more than two decades to treat…
PMID42486217DOI10.1016/j.biopsych.2026.07.010연구 유형기타학술지Biological psychiatry
https://pubmed.ncbi.nlm.nih.gov/42486217/문헌 23tirzepatideICSR 검토우선순위 중간
Multi-target-directed drugs: new additions in 2025 and post-marketing safety surveillance of drugs marketed in 2022-2024.
Polypharmacology is dedicated to the development of compounds acting on at least two targets (multi-target-directed ligands, MTDLs). In 2025, the European Medicines Agency (EMA) approved 38 drugs, and 11 out of them were MTDLs. Most of them are antibody-drug conjugates, bispecific antibodies, or ki…
PMID42484993DOI10.1007/s43440-026-00879-x연구 유형기타학술지Pharmacological reports : PR
https://pubmed.ncbi.nlm.nih.gov/42484993/문헌 24semaglutide근거 검토우선순위 낮음
Cost-Effectiveness of Endoscopic Bariatric Therapies Compared with Laparoscopic Sleeve Gastrectomy and Semaglutide.
Endoscopic bariatric therapies, including endoscopic sleeve gastroplasty (ESG) and intragastric balloon (IGB), are emerging as less invasive alternatives to bariatric surgery. However, their economic value relative to established treatments such as bariatric surgery and pharmacotherapy remains unce…
PMID42484827DOI10.1007/s11695-026-08854-4연구 유형기타학술지Obesity surgery
https://pubmed.ncbi.nlm.nih.gov/42484827/문헌 25semaglutide근거 검토우선순위 낮음
Implications of Generic Semaglutide Availability on the Cost-Effectiveness of GLP-1RA for Guideline-Indicated Patients With Type 2 Diabetes.
PubMed에 초록이 제공되지 않았습니다.
PMID42484591DOI10.1016/j.cjca.2026.05.013연구 유형기타학술지The Canadian journal of cardiology
https://pubmed.ncbi.nlm.nih.gov/42484591/문헌 26semaglutide근거 검토우선순위 낮음
Safety Signals of GLP-1 Receptor Agonists: A Multi-Method Pharmacovigilance Analysis of FAERS (2018-2025) With Sensitivity-Stratified Prioritisation, Notoriety-Bias Assessment, and Cross-Database Validation.
GLP-1 receptor agonists (GLP-1 RAs) are widely prescribed for type 2 diabetes and obesity, but their post-marketing safety profile-particularly psychiatric, vascular, neoplastic and rare ophthalmic events-remains incompletely characterised and is vulnerable to confounding by indication, secondary-s…
PMID42481928DOI10.1111/dom.71138연구 유형기타학술지Diabetes, obesity & metabolism
https://pubmed.ncbi.nlm.nih.gov/42481928/문헌 27semaglutideICSR 검토우선순위 중간
Host-directed treatments for tuberculous meningitis utilizing a multi-platform approach across mouse and human models.
Tuberculous meningitis (TB meningitis) is a major cause of death and neurological deficit despite recommended antibiotic and corticosteroid treatments, primarily due to dysregulated neuroinflammation. Here, we investigate a diverse panel of 12 immunomodulatory drugs as host-directed treatments (HDT…
PMID42481504DOI10.1038/s41467-026-75202-6연구 유형기타학술지Nature communications
https://pubmed.ncbi.nlm.nih.gov/42481504/문헌 28tirzepatide근거 검토우선순위 낮음
Association between GLP-1 receptor agonists and alcohol-related hospitalisations among adults with alcohol use disorder: multi-target trial emulation study.
To evaluate the association between use of newer glucagon-like peptide-1 receptor agonists (GLP-1 RAs; semaglutide, tirzepatide) and alcohol-related hospitalisations among adults with alcohol use disorder (AUD) and type 2 diabetes (T2D) or obesity.Retrospective cohort study using target trial emula…
PMID42481079DOI10.1136/bmjopen-2025-109259연구 유형기타학술지BMJ open
https://pubmed.ncbi.nlm.nih.gov/42481079/문헌 29semaglutide근거 검토우선순위 낮음
From FLOW to translational positioning in chronic kidney disease: mechanistic complementarity of SGLT2 inhibitors and GLP-1 receptor agonists.
Chronic kidney disease is a central node of the cardio-kidney-metabolic continuum and carries substantial residual cardiovascular and kidney risk. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have reproducibly reduced kidney disease progression and heart failure risk in CKD outcomes trials, w…
PMID42480913DOI10.1016/j.trsl.2026.07.008연구 유형기타학술지Translational research : the journal of laboratory and clinical medicine
https://pubmed.ncbi.nlm.nih.gov/42480913/문헌 30tirzepatideICSR 검토우선순위 중간
GLP-1 Receptor Agonists as a Candidate Treatment for Opioid Use Disorder: From rats to humans.
Despite recent progress, and at least three medications approved for the treatment of opioid use disorder (OUD), the number of deaths due to opioid overdose remains unacceptably high. As such, there is need for new treatments. To this end, glucagon-like peptide-1 receptor agonists (GLP-1RAs), dual…
PMID42480803DOI10.1016/j.biopsych.2026.06.033연구 유형기타학술지Biological psychiatry
https://pubmed.ncbi.nlm.nih.gov/42480803/문헌 31tirzepatideICSR 검토우선순위 중간
Respiratory Adverse Events of Weight-Loss Drugs: A Systematic Review and Meta-Analysis.
The coexistence of obesity and asthma is increasingly common and associated with poorer asthma outcomes. Weight loss has been shown to improve asthma outcomes. Although several effective weight-loss medications are available, evidence regarding their respiratory effects remains limited. To conduct…
PMID42479131DOI10.1093/annalsats/aaoag177연구 유형기타학술지Annals of the American Thoracic Society
https://pubmed.ncbi.nlm.nih.gov/42479131/문헌 32semaglutideICSR 검토우선순위 중간
Oral Semaglutide and CV Benefits in the SOUL Trial: How Do Baseline or Changes in HbA1c or BMI Affect Clinical Outcomes?
In the SOUL trial (NCT03914326), oral semaglutide reduced risk of major adverse cardiovascular (CV) events (MACE) by 14%. Whether baseline or changes in HbA1c or BMI are associated with these CV benefits is not known. We evaluated whether CV benefits of oral semaglutide are associated with baseline…
PMID42478869DOI10.1210/clinem/dgag290연구 유형기타학술지The Journal of clinical endocrinology and metabolism
https://pubmed.ncbi.nlm.nih.gov/42478869/문헌 33tirzepatide근거 검토우선순위 낮음
Preventative semaglutide and tirzepatide treatment does not alter disease progression in the 5xFAD mouse model of Alzheimer's disease.
There is growing evidence that long-acting mimetics of the gut-derived incretin hormones GLP-1 and GIP act as disease-modifying therapies for Alzheimer's disease (AD). Here, we temporally characterize the efficacy of the approved incretin receptor agonists semaglutide, a GLP-1R agonist, and tirzepa…
PMID42413499DOI10.1016/j.xcrm.2026.102906연구 유형기타학술지Cell reports. Medicine
https://pubmed.ncbi.nlm.nih.gov/42413499/문헌 34tirzepatideICSR 검토우선순위 중간
Tirzepatide-Induced Weight Loss and Exacerbation of Bipolar Disorder With Clozapine Treatment: A Case Report.
PubMed에 초록이 제공되지 않았습니다.
PMID42495981DOI10.1097/JCP.0000000000002241연구 유형기타학술지Journal of clinical psychopharmacology
https://pubmed.ncbi.nlm.nih.gov/42495981/문헌 35tirzepatideICSR 검토우선순위 중간
One receptor, two opposite approaches: efficacy and tolerability of GIPR agonism and antagonism in obesity pharmacotherapy.
Glucagon-like peptide-1 receptor (GLP-1R) agonists have transformed obesity pharmacotherapy, producing clinically meaningful weight loss and robust improvements in glycemic control. Yet their efficacy remains constrained by dose-limiting gastrointestinal adverse effects, including nausea and vomiti…
PMID42492687DOI10.1016/j.appet.2026.108723연구 유형기타학술지Appetite
https://pubmed.ncbi.nlm.nih.gov/42492687/문헌 36tirzepatideICSR 검토우선순위 중간
Cardiovascular Outcomes of GLP-1-Based Medicines Among People With Overweight and Obesity: An Umbrella Review of Meta-Analyses of Randomized Controlled Trials.
Cardiovascular (CV) outcomes of Glucagon-like peptide-1 (GLP-1)-based medicines among people with overweight and obese (OW/OB) population have been investigated by meta-analyses of randomized controlled trials (RCTs), but an overall summary is lacking. PubMed, EMBASE, Epistemonikos, and Cochrane da…
PMID42483841DOI10.1111/obr.70198연구 유형기타학술지Obesity reviews : an official journal of the International Association for the Study of Obesity
https://pubmed.ncbi.nlm.nih.gov/42483841/문헌 37tirzepatide근거 검토우선순위 낮음
Effect of tirzepatide on body weight in Czech soldiers.
PubMed에 초록이 제공되지 않았습니다.
PMID40750116DOI10.1136/military-2025-003076연구 유형기타학술지BMJ military health
https://pubmed.ncbi.nlm.nih.gov/40750116/문헌 38tirzepatide근거 검토우선순위 낮음
Obese and overweight patients with type 2 diabetes mellitus are not treated optimally - an overview of current clinical practice and future perspectives.
Type 2 diabetes mellitus (T2DM) pharmacotherapy guidelines recommend the assessment of individual cardiovascular (CV) risk. However, obesity still seems of lesser importance in the context of CV risk. Importantly, obesity-targeting pharmacotherapy use is limited. A PubMed database search, up to Aug…
PMID42467408DOI10.1080/17512433.2026.2706660연구 유형기타학술지Expert review of clinical pharmacology
https://pubmed.ncbi.nlm.nih.gov/42467408/문헌 39tofacitinib근거 검토우선순위 낮음
Evaluating the cardiometabolic impact of Janus-kinase inhibition: An experimental analysis of Tofacitinib's therapeutic potential in a rodent model.
Rheumatoid arthritis (RA) is the most prevalent non-infectious inflammatory disorder, often associated with comorbidities such as cardiovascular alterations and metabolic syndrome. These comorbidities significantly influence RA activity, flare duration, and treatment outcomes. This study investigat…
PMID42497584DOI10.1016/j.biopha.2026.119772연구 유형기타학술지Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
https://pubmed.ncbi.nlm.nih.gov/42497584/문헌 40tofacitinibICSR 검토우선순위 중간
Successful Management of Persistent DRESS with Tofacitinib: Two Case Reports.
PubMed에 초록이 제공되지 않았습니다.
PMID42494232DOI10.1111/ddg.70408연구 유형기타학술지Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
https://pubmed.ncbi.nlm.nih.gov/42494232/문헌 41tofacitinib근거 검토우선순위 낮음
[Sustained complete remission achieved with tofacitinib in a refractory T-cell large granular lymphocytic leukemia].
Treatment of large granular lymphocytic leukemia, particularly T-cell leukemia (LGL-T), remains challenging. JAK inhibitors, although still scarcely evaluated, appear promising. An 85-year-old woman was treated for a refractory LGL-T associated with neutropenia, unclassified polyarthritis and vitil…
PMID42486736DOI10.1016/j.revmed.2026.07.001연구 유형기타학술지La Revue de medecine interne
https://pubmed.ncbi.nlm.nih.gov/42486736/문헌 42tofacitinibICSR 검토우선순위 중간
Effectiveness of tofacitinib as rescue therapy in biological-naive patients with steroid-refractory acute severe ulcerative colitis: a multicentric retrospective analysis.
Tofacitinib, a Janus kinase inhibitor approved for moderate-to-severe ulcerative colitis, has limited data in acute severe ulcerative colitis (ASUC), particularly in biologic-naive patients. This study evaluated its safety and efficacy as second-line therapy after intravenous steroid failure. The p…
PMID42485112DOI10.1097/MEG.0000000000003254연구 유형기타학술지European journal of gastroenterology & hepatology
https://pubmed.ncbi.nlm.nih.gov/42485112/문헌 43tofacitinibICSR 검토우선순위 중간
Varicella-zoster virus reactivation and cardiovascular risk: implications for patients receiving JAK inhibitors.
Varicella-zoster virus (VZV) is a neurotropic herpesvirus responsible for varicella and herpes zoster. Beyond its classical clinical manifestations, recent evidence shows that VZV reactivation may contribute to acute cardiovascular events. Vaccination reduces the incidence of herpes zoster and may…
PMID42476902DOI10.1016/j.ard.2026.06.027연구 유형기타학술지Annals of the rheumatic diseases
https://pubmed.ncbi.nlm.nih.gov/42476902/문헌 44tofacitinibICSR 검토우선순위 중간
Vulvovaginal Lichen Planus Treatment Outcomes: A Systematic Review of Novel and Established Therapies.
Vulvovaginal lichen planus (VVLP) is a chronic inflammatory mucocutaneous disease causing significant morbidity. Despite various available treatments, evidence regarding their effectiveness remains fragmented. To systematically evaluate the efficacy and safety of therapeutic interventions for VVLP…
PMID42473437DOI10.1177/12034754261458384연구 유형기타학술지Journal of cutaneous medicine and surgery
https://pubmed.ncbi.nlm.nih.gov/42473437/문헌 45valproateICSR 검토우선순위 중간
A combined in silico and in vitro new approach methodology for early detection of liver steatogenic chemicals.
Fatty liver disease is the most prevalent hepatic pathology, with accumulating evidence suggesting that chemical exposure may contribute to its development and progression. Consequently, mechanistic understanding of perturbations leading to liver steatosis is essential for chemical safety assessmen…
PMID42173389DOI10.1016/j.cbi.2026.112153연구 유형기타학술지Chemico-biological interactions
https://pubmed.ncbi.nlm.nih.gov/42173389/문헌 46valproateICSR 검토우선순위 중간
Fenfluramine in refractory SCN1A -related 'genetic epilepsy with febrile seizures plus'.
A child with SCN1A -related 'genetic epilepsy with febrile seizures plus' (GEFS+) presented in infancy with recurrent febrile and afebrile seizures, frequently progressing to generalised tonic-clonic status epilepticus. Despite a severe seizure burden and typical Dravet-like triggers, neurodevelopm…
PMID42498321DOI10.1136/bcr-2026-273440연구 유형기타학술지BMJ case reports
https://pubmed.ncbi.nlm.nih.gov/42498321/문헌 47valproate근거 검토우선순위 낮음
Research advances in key genes and regulatory mechanisms of posttranslational modifications in Parkinson's disease.
The genesis of Parkinson's disease (PD), a common central neurodegenerative disorder, involves dysregulation of protein posttranslational modifications (PTM). The primary objective of this study was to screen key PTM-associated genes (PTMGs) serving as diagnostic indicators and potential therapeuti…
PMID42497137DOI10.1371/journal.pone.0354097연구 유형기타학술지PloS one
https://pubmed.ncbi.nlm.nih.gov/42497137/문헌 48valproate근거 검토우선순위 낮음
Trigonelline attenuates valproic acid-induced autism-like behaviours in rats: histopathological changes of the hippocampus, modulation of gene expressions related to neuroinflammation and blood-brain barrier permeability.
Autism spectrum disorders (ASD) is a neurodevelopmental disorder. Neuroinflammation and bloodbrain barrier (BBB) dysfunction have role in the pathophysiology of ASD. Trigonelline (TRI) exerted neuroprotective effects. We aimed to investigate TRI's effects on autistic phenotype, gene expression of t…
PMID42496985DOI10.1080/15622975.2026.2702428연구 유형기타학술지The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
https://pubmed.ncbi.nlm.nih.gov/42496985/문헌 49valproateICSR 검토우선순위 중간
The effectiveness of adding on or switching antiseizure medications after the first fails to control focal epilepsy: A systematic review of randomized controlled trials.
Focal epilepsy constitutes 60-70% of epilepsy, and up to half of patients do not achieve seizure freedom with their first antiseizure medication (ASM). When the first ASM fails, evidence guiding whether to switch or add-on another ASM and which ASMs to use is limited. This review synthesized eviden…
PMID42495800DOI10.1002/epd2.70353연구 유형기타학술지Epileptic disorders : international epilepsy journal with videotape
https://pubmed.ncbi.nlm.nih.gov/42495800/문헌 50valproate근거 검토우선순위 낮음
Improving evidence-based antiseizure medication prescribing during pregnancy: strengthening research and clinical practice.
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PMID42464699DOI10.1080/17512433.2026.2705845연구 유형기타학술지Expert review of clinical pharmacology
https://pubmed.ncbi.nlm.nih.gov/42464699/문헌 51valproateICSR 검토우선순위 중간
Infertility treatment in women with epilepsy: A systematic review.
The impact of assisted reproductive technologies (ART) on seizure control in women with epilepsy remains incompletely understood. A systematic review was conducted according to PRISMA guidelines. EMBASE, MEDLINE, CINAHL, Scopus, and the Cochrane Library were searched from inception to March 2025. E…
PMID42492305DOI10.1016/j.yebeh.2026.111210연구 유형기타학술지Epilepsy & behavior : E&B
https://pubmed.ncbi.nlm.nih.gov/42492305/문헌 52valproateICSR 검토우선순위 중간
Valproate vs levetiracetam in juvenile myoclonic epilepsy: systematic review and meta-analysis.
Juvenile myoclonic epilepsy (JME) is a genetic generalized epilepsy syndrome with onset typically in adolescence and a chronic course requiring long-term antiseizure medications (ASMs). Valproate (VPA) is the most effective treatment for seizure control in JME but use is limited by metabolic, cogni…
PMID42492303DOI10.1016/j.yebeh.2026.111208연구 유형기타학술지Epilepsy & behavior : E&B
https://pubmed.ncbi.nlm.nih.gov/42492303/문헌 53valproate근거 검토우선순위 낮음
Systematic pan-cancer analysis identifies PIK3R3 as a lipid metabolism and immune regulation prognostic biomarker.
We aimed to explore the critical role of PIK3R3 in pan-cancer, which to facilitate the development of more targeted prognostic markers and therapeutic strategies for these malignancies. In our study, pan-cancer transcriptome datasets were retrieved from Xena database. Subsequently, utilizing the Wi…
PMID42483220DOI10.1515/med-2026-1439연구 유형기타학술지Open medicine (Warsaw, Poland)
https://pubmed.ncbi.nlm.nih.gov/42483220/문헌 54valproate근거 검토우선순위 낮음
Ubiquitination-related gene signature in photoaging and prediction of candidate therapeutic agents.
Photoaging is the major type of exogenous aging caused by chronic ultraviolet (UV) radiation, whose pathogenesis is complex and not fully understood. Recently, the involvement of ubiquitination in aging and aging-related disorders has aroused extensive attention. The present study aimed to investig…
PMID42478501DOI10.1111/php.70138연구 유형기타학술지Photochemistry and photobiology
https://pubmed.ncbi.nlm.nih.gov/42478501/