Multi-target-directed drugs: new additions in 2025 and post-marketing safety surveillance of drugs marketed in 2022-2024.

저자: Piotr Ryszkiewicz, Marta Baranowska-Kuczko, Barbara Malinowska, Eberhard Schlicker
저널: Pharmacological reports : PR
공개일: 2026 Jul 22
연구 유형: 기타
DOI: 10.1007/s43440-026-00879-x

문헌 요약

Polypharmacology is dedicated to the development of compounds acting on at least two targets (multi-target-directed ligands, MTDLs). In 2025, the European Medicines Agency (EMA) approved 38 drugs, and 11 out of them were MTDLs. Most of them are antibody-drug conjugates, bispecific antibodies, or kinase inhibitors, all of which are indicated for tumor trea…

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