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LITERATURE DETAIL · PMID 42482528
Automated DNA-Encoded Library Synthesis and Activity-Based Screening at the Attomole Scale.
Automated DNA-Encoded Library Synthesis and Activity-Based Screening at the Attomole Scale.
- 저자
- John P Burdick, Erika M Cerna Arroyo, Samantha R Levine, Brian M Paegel
- 저널
- Journal of medicinal chemistry
- 공개일
- 2026 Jul 21
- 연구 유형
- 기타
- DOI
- 10.1021/acs.jmedchem.6c01339
문헌 요약
One-bead-one-compound DNA-encoded library (OBOC-DEL) technology enables synthesis and activity-based screening of diverse compound collections but requires complex microfluidic instrumentation and laborious manual bead handling. Here, we execute DEL synthesis on 2.8-μm-dia magnetic beads and encapsulate them in a functionalized polyacrylamide hydrogel to…
PV 검토 포인트
누적 안전성 근거로 분류하고 기존 시그널과의 일관성을 확인합니다.