valproate우선순위 중간ICSR 검토기타
LITERATURE DETAIL · PMID 42173389
A combined in silico and in vitro new approach methodology for early detection of liver steatogenic chemicals.
A combined in silico and in vitro new approach methodology for early detection of liver steatogenic chemicals.
- 저자
- Anouk Verhoeven, Domenico Gadaleta, Nisreen H K Isbaita, Jian Jiang, Julen Sanz-Serrano, Eva Serrano-Candelas
- 저널
- Chemico-biological interactions
- 공개일
- 2026 Jul 25
- 연구 유형
- 기타
- DOI
- 10.1016/j.cbi.2026.112153
문헌 요약
Fatty liver disease is the most prevalent hepatic pathology, with accumulating evidence suggesting that chemical exposure may contribute to its development and progression. Consequently, mechanistic understanding of perturbations leading to liver steatosis is essential for chemical safety assessment. This study introduces a new approach methodology (NAM),…
PV 검토 포인트
개별 증례 가능성과 중대성, 예상성 및 중복 여부를 우선 검토합니다.