valproate우선순위 낮음근거 검토기타
LITERATURE DETAIL · PMID 42496985
Trigonelline attenuates valproic acid-induced autism-like behaviours in rats: histopathological changes of the hippocampus, modulation of gene expressions related to neuroinflammation and blood-brain barrier permeability.
Trigonelline attenuates valproic acid-induced autism-like behaviours in rats: histopathological changes of the hippocampus, modulation of gene expressions related to neuroinflammation and blood-brain barrier permeability.
- 저자
- Zahra Forouzandeh Shahraki, Ali Noori, Hossein Amini-Khoei, Nasrin Yazdanpanahi, Mahnoosh Fatemi
- 저널
- The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
- 공개일
- 2026 Jul 24
- 연구 유형
- 기타
- DOI
- 10.1080/15622975.2026.2702428
문헌 요약
Autism spectrum disorders (ASD) is a neurodevelopmental disorder. Neuroinflammation and bloodbrain barrier (BBB) dysfunction have role in the pathophysiology of ASD. Trigonelline (TRI) exerted neuroprotective effects. We aimed to investigate TRI's effects on autistic phenotype, gene expression of tight junction proteins associated with BBB integrity, neur…
PV 검토 포인트
누적 안전성 근거로 분류하고 기존 시그널과의 일관성을 확인합니다.