valproate우선순위 낮음근거 검토기타
LITERATURE DETAIL · PMID 42634932
Assessment of the impact of valproic acid co-administration on clozapine plasma concentrations in Tunisian patients.
Assessment of the impact of valproic acid co-administration on clozapine plasma concentrations in Tunisian patients.
- 저자
- Syrine Ben Hammamia, Safa Souissi, Mariem Bettoumia, Mouna Ben Sassi, Khouloud Ferchichi, Mouna Daldoul
- 저널
- Drug metabolism and personalized therapy
- 공개일
- 2026 Aug 25
- 연구 유형
- 기타
- DOI
- 10.1515/dmpt-2026-0018
문헌 요약
Reports on drug-drug interactions between Valproic Acid (VPA) and Clozapine (CLZ) are very inconsistent. Previous reports demonstrate that VPA may exhibit either inhibitory or inductive effects or have no effect on CLZ pharmacokinetics. The aim of this study was to investigate the impact of VPA on plasma CLZ concentrations in a series of Tunisian patients…
PV 검토 포인트
누적 안전성 근거로 분류하고 기존 시그널과의 일관성을 확인합니다.