문헌 01apixabanICSR 검토우선순위 중간
Predictive value of CHA 2 DS 2 -VASc score for long-term outcomes after large vessel occlusion in patients with non-valvular atrial fibrillation.
The CHA 2 DS 2 -VASc score assesses the stroke risk in patients with atrial fibrillation (AF). This study determined the predictive value of the CHA 2 DS 2 -VASc score for long-term outcomes after acute ischemic stroke (AIS) with large vessel occlusion (LVO) in patients with AF. Patients with AF wh…
PMID42105615DOI10.1016/j.jns.2026.125976연구 유형기타학술지Journal of the neurological sciences
https://pubmed.ncbi.nlm.nih.gov/42105615/문헌 02rivaroxaban근거 검토우선순위 낮음
Microcolumn Liquid Chromatography-Atmospheric Pressure Chemical Ionisation Tandem Mass Spectrometric Determination of Nitrosamine Impurities From Pharmaceutical Products.
Pharmaceutical analysis is vital for assessing drug quality and identifying impurities. The recent emergence of carcinogenic nitrosamine contaminants has escalated scrutiny, resulting in the withdrawal of multiple medications. This study focuses on developing robust analytical techniques to detect…
PMID42065343DOI10.1002/rcm.70095연구 유형기타학술지Rapid communications in mass spectrometry : RCM
https://pubmed.ncbi.nlm.nih.gov/42065343/문헌 03apixaban근거 검토우선순위 낮음
Apixaban, direct oral anticoagulants and psychiatric events: Innocent bystander or true safety signal?
PubMed에 초록이 제공되지 않았습니다.
PMID41966230DOI10.1016/j.jad.2026.121752연구 유형기타학술지Journal of affective disorders
https://pubmed.ncbi.nlm.nih.gov/41966230/문헌 04warfarinICSR 검토우선순위 중간
Real-World Effectiveness and Safety of Direct Oral Anticoagulants Versus Warfarin in Patients With Atrial Fibrillation and Mitral Stenosis : A Target Trial Emulation.
Whether direct oral anticoagulants (DOACs) are a safe and effective alternative to warfarin in patients with atrial fibrillation and mitral stenosis (AF-MS) remains controversial. To evaluate the effectiveness and safety of DOACs versus warfarin in patients with AF-MS. Observational cohort study us…
PMID42574730DOI10.7326/ANNALS-25-04740연구 유형기타학술지Annals of internal medicine
https://pubmed.ncbi.nlm.nih.gov/42574730/문헌 05warfarin근거 검토우선순위 낮음
Calciphylaxis in chronic kidney disease: a systematic review of pathomechanisms and risk factors for calcific uremic arteriolopathy.
Calcific uremic arteriolopathy (CUA) is a rare, severe condition affecting patients with chronic kidney disease (CKD). The etiology of CUA is unclear. Here, we aimed to identify factors associated with its development. We reviewed the existing evidence on its pathomechanisms and risk factors. We se…
PMID42572798DOI10.1080/0886022X.2026.2710397연구 유형기타학술지Renal failure
https://pubmed.ncbi.nlm.nih.gov/42572798/문헌 06tirzepatideICSR 검토우선순위 중간
Depressed mood and suicidal thoughts reporting with GLP-1 receptor agonists in type 2 diabetes: A WHO VigiBase study.
Evidence regarding depression and suicidality with glucagon-like peptide-1 receptor agonists (GLP-1RAs) remains inconsistent, particularly in patients with type 2 diabetes mellitus (T2DM) and underlying affective vulnerability. We conducted a disproportionality analysis of the WHO VigiBase (2010-20…
PMID42002107DOI10.1016/j.jad.2026.121802연구 유형기타학술지Journal of affective disorders
https://pubmed.ncbi.nlm.nih.gov/42002107/문헌 07semaglutide근거 검토우선순위 낮음
AgRP neurons are required for the weight-lowering effects of GLP-1 receptor agonists in female mice.
Glucagon-like peptide-1 receptor agonists (GLP-1RAs), including semaglutide, produce robust and sustained weight loss, yet the central mechanisms supporting their long-term efficacy remain incompletely understood. Agouti-related peptide (AgRP) neurons of the arcuate nucleus are classically activate…
PMID42550908DOI10.1073/pnas.2614476123연구 유형기타학술지Proceedings of the National Academy of Sciences of the United States of America
https://pubmed.ncbi.nlm.nih.gov/42550908/문헌 08tirzepatide근거 검토우선순위 낮음
Prescribed but Not Filled: Patient Factors Related to Semaglutide/Tirzepatide Prescription Fills Among Those With Prescription Orders for Obesity Treatment.
PubMed에 초록이 제공되지 않았습니다.
PMID42575862DOI10.1111/dom.71199연구 유형기타학술지Diabetes, obesity & metabolism
https://pubmed.ncbi.nlm.nih.gov/42575862/문헌 09semaglutide근거 검토우선순위 낮음
AI Patient Support and 6-Month Medication Adherence in a Digital Obesity Program: A Retrospective Analysis.
Real-world glucagon-like peptide-1 receptor agonist (GLP-1 RA) therapies face substantial attrition rates in commercial digital weight loss services (DWLSs). Conversational artificial intelligence (AI) has been proposed to enhance patient support at production scale, but robust evidence of its effe…
PMID42575845DOI10.1111/dom.71181연구 유형기타학술지Diabetes, obesity & metabolism
https://pubmed.ncbi.nlm.nih.gov/42575845/문헌 10tirzepatide근거 검토우선순위 낮음
Changes in recorded background glucose-lowering therapy after initiation of a GLP-1 receptor agonist or dual GIP/GLP-1 receptor agonist in adults with type 2 diabetes.
To evaluate changes in recorded background glucose-lowering active-substance counts after initiation of a glucagon-like peptide-1 (GLP-1) or dual GIP/GLP-1 receptor agonist. This retrospective cohort study used anonymized electronic health records from a large Polish private outpatient network. Adu…
PMID42575344DOI10.1016/j.diabres.2026.113493연구 유형기타학술지Diabetes research and clinical practice
https://pubmed.ncbi.nlm.nih.gov/42575344/문헌 11semaglutide근거 검토우선순위 낮음
First Approval of Semaglutide for MASH in India: A Paradigm Shift in MASLD Management?
PubMed에 초록이 제공되지 않았습니다.
PMID42575231DOI10.1016/j.drudis.2026.104762연구 유형기타학술지Drug discovery today
https://pubmed.ncbi.nlm.nih.gov/42575231/문헌 12semaglutideICSR 검토우선순위 중간
Efficacy and safety of once-weekly semaglutide 2·4 mg in Chinese adults with overweight or obesity (STEP 12): a randomised, double-blind, placebo-controlled, multicentre, phase 3b trial.
Semaglutide 2·4 mg is a GLP-1 receptor agonist that reduces bodyweight, and provides other cardiometabolic benefits, among people with a BMI at least 30 kg/m 2 or at least 27 kg/m 2 and with weight-related comorbidities. This trial aimed to evaluate the efficacy, tolerability, and safety of semaglu…
PMID42575111DOI10.1016/S2213-8587(26)00133-6연구 유형기타학술지The lancet. Diabetes & endocrinology
https://pubmed.ncbi.nlm.nih.gov/42575111/문헌 13semaglutide근거 검토우선순위 낮음
Perioperative management of GLP-1 receptor agonists: a structured narrative review with considerations relevant to neurosurgical patients.
The use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) is increasing in the treatment of obesity and type 2 diabetes mellitus. Some patients taking these medications undergo cranial or spinal surgical procedures. Delayed gastric emptying is a key mechanism of action for these medications.…
PMID42573674DOI10.1007/s40618-026-03004-0연구 유형기타학술지Journal of endocrinological investigation
https://pubmed.ncbi.nlm.nih.gov/42573674/문헌 14semaglutide근거 검토우선순위 낮음
Semaglutide as a potential neuroprotective agent for neurological and neurodegenerative disorders: Mechanisms, preclinical evidence, and translational challenges and opportunities.
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are established treatments for metabolic disease, with growing evidence suggesting neuroprotective potential in central nervous system (CNS) disorders. In preclinical models of Alzheimer's disease (AD), Parkinson's disease (PD), multiple scleros…
PMID42573665DOI10.1007/s11033-026-12549-5연구 유형기타학술지Molecular biology reports
https://pubmed.ncbi.nlm.nih.gov/42573665/문헌 15tirzepatide근거 검토우선순위 낮음
GLP-1-Based Therapies in Pain Medicine: A Narrative Review and Expert Opinion on Obesity-Related Low Back and Knee Pain.
Obesity is highly prevalent among patients with chronic musculoskeletal pain and is associated with low back pain, knee osteoarthritis, reduced mobility, and poorer functional outcomes. Glucagon-like peptide-1 (GLP-1) receptor agonists and related therapies have transformed obesity medicine and may…
PMID42572056DOI10.1007/s11916-026-01546-9연구 유형기타학술지Current pain and headache reports
https://pubmed.ncbi.nlm.nih.gov/42572056/문헌 16tirzepatide근거 검토우선순위 낮음
Tirzepatide Persistence and Associated Changes in Clinical Outcomes in US Adults With Obesity or Overweight: A 6-Month Claims Database Analysis.
Tirzepatide is a once-weekly glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist (GLP-1 RA) approved in the US for the treatment of Type 2 diabetes (T2D), weight loss and obstructive sleep apnoea. This study aimed to assess the utilisation and effectiveness of…
PMID42575714DOI10.1111/dom.71064연구 유형기타학술지Diabetes, obesity & metabolism
https://pubmed.ncbi.nlm.nih.gov/42575714/문헌 17tirzepatide근거 검토우선순위 낮음
Tirzepatide Use Is Associated with Reduced Risk of Carpal Tunnel Syndrome in Overweight and Obese Adults.
This study aimed to evaluate the association between tirzepatide use and the risk of carpal tunnel syndrome (CTS) and CTS surgery compared with both glucagon-like peptide-1 receptor agonists (GLP-1RAs) and other anti-obesity medications in individuals who are overweight or obese. We conducted a mul…
PMID42572932DOI10.1002/cpt.70440연구 유형기타학술지Clinical pharmacology and therapeutics
https://pubmed.ncbi.nlm.nih.gov/42572932/문헌 18tirzepatide근거 검토우선순위 낮음
Predicted 10-Year Cardiovascular Disease Risk Reduction with Tirzepatide Use Over Three Years for Primary Prevention of Cardiovascular Disease in Obesity.
This post hoc analysis assessed the durability of tirzepatide for primary cardiovascular disease (CVD) prevention in obesity, based on predicted CVD risk, in the SURMOUNT-1 (SM-1) 3-year study. SM-1 was a phase 3, double-blind, randomised trial where individuals with obesity/overweight and prediabe…
PMID42572119DOI10.1093/eurjpc/zwag408연구 유형기타학술지European journal of preventive cardiology
https://pubmed.ncbi.nlm.nih.gov/42572119/문헌 19tofacitinib근거 검토우선순위 낮음
Polymeric mixed micellar nanogel enhances dermal delivery and therapeutic efficacy of tofacitinib citrate.
This study aimed to develop and evaluate a polymeric-surfactant stabilized mixed micellar (MM) gel of tofacitinib citrate (TFC) for localized management of rheumatoid arthritis (RA). TFC-MM gel was formulated via a simple and scalable cold dispersion self-assembly approach using Lipoid S75, Tween 8…
PMID42401300DOI10.1016/j.ijpharm.2026.127154연구 유형기타학술지International journal of pharmaceutics
https://pubmed.ncbi.nlm.nih.gov/42401300/문헌 20valproateICSR 검토우선순위 중간
Efficacy and safety of pharmacological interventions for the maintenance of bipolar disorder: A systematic review and dose-related network meta-analysis across different age groups.
Bipolar disorder (BD) is a chronic mental illness that requires lifelong treatment. We investigated the comparative efficacy and safety of pharmacological interventions for bipolar maintenance, considering dose effects across different age groups. We conducted a network meta-analysis (NMA) of rando…
PMID41985753DOI10.1016/j.jad.2026.121798연구 유형기타학술지Journal of affective disorders
https://pubmed.ncbi.nlm.nih.gov/41985753/문헌 21valproateICSR 검토우선순위 중간
Risk of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis After Initiation of Antiseizure Medication: A Danish Nationwide Cohort Study.
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious cutaneous adverse reactions associated with several antiseizure medications, particularly lamotrigine and carbamazepine. We assessed the 90-day absolute risk of SJS/TEN after initiation of antiseizure medications in a n…
PMID42467870DOI10.1212/WNL.0000000000218355연구 유형기타학술지Neurology
https://pubmed.ncbi.nlm.nih.gov/42467870/문헌 22valproate근거 검토우선순위 낮음
Sequential Biofunctionalization of a Choline-Based Monomeric Ionic Liquid and Polymerized Ionic Liquid: A Route to Dual Anionic Drug Polymer Conjugates of Piperacillin-Tazobactam.
The choline-based monomeric ionic liquid (MIL), that is, [2-(methacryloyloxy)ethyl]trimethylammonium chloride (TMAMA), was modified by ion exchange to introduce a pharmaceutical anion (aspartic acid (APT), diclofenac (DIC), cholic acid (CHA), ibuprofen (IBU), nalidixic acid (NAL), naproxen (NAP), p…
PMID42390211DOI10.1021/acsbiomaterials.6c00377연구 유형기타학술지ACS biomaterials science & engineering
https://pubmed.ncbi.nlm.nih.gov/42390211/