tirzepatide우선순위 낮음근거 검토기타
LITERATURE DETAIL · PMID 42630988
Comparative effects of semaglutide tirzepatide and retatrutide on renal fibrosis in UUO and aged mice.
Comparative effects of semaglutide tirzepatide and retatrutide on renal fibrosis in UUO and aged mice.
- 저자
- Mingling Ding, Xiaoxiao Li, Yuchao Wei, Jitong Wang, Bohan Jiao, Caiyue Li
- 저널
- iScience
- 공개일
- 2026 Sep 18
- 연구 유형
- 기타
- DOI
- 10.1016/j.isci.2026.117174
문헌 요약
Chronic kidney disease is a major health burden. Given the therapeutic potential of GLP-1 receptor agonists (semaglutide, tirzepatide, and retatrutide) in diabetic nephropathy, we evaluated their anti-fibrotic and anti-inflammatory effects in non-diabetic renal fibrosis using HK-2 cells and murine UUO and aging models. Integrating in vivo and in vitro dat…
PV 검토 포인트
누적 안전성 근거로 분류하고 기존 시그널과의 일관성을 확인합니다.