문헌 01dabigatranICSR 검토우선순위 중간
Real-world evidence on off-label underdosing of direct oral anticoagulants in Asian patients with atrial fibrillation: prescribing patterns, determinants, and outcomes.
Off-label underdosing of direct oral anticoagulants (DOACs) is common among Asian patients with atrial fibrillation (AF), partly reflecting concerns about bleeding, yet Southeast Asian data remain limited. This study aimed to characterize DOAC dosing patterns, identify predictors of off-label under…
PMID42544439DOI10.1080/20565623.2026.2708024연구 유형기타학술지Future science OA
https://pubmed.ncbi.nlm.nih.gov/42544439/문헌 02apixabanICSR 검토우선순위 중간
Oral anticoagulants reduce venous thromboembolism rates in patients on 1st-line treatment for ovarian Cancer- A quality improvement project.
Metastatic cancer patients receiving systemic chemotherapy face increased risks for venous thromboembolism (VTE). Benefit has been shown for prophylactic anticoagulants in risk-stratified populations. Ovarian cancer (OC) is commonly advanced at diagnosis and treated with chemotherapy. Despite high…
PMID42561468DOI10.1016/j.ygyno.2026.07.018연구 유형기타학술지Gynecologic oncology
https://pubmed.ncbi.nlm.nih.gov/42561468/문헌 03warfarinICSR 검토우선순위 중간
AI-generated patient information leaflets for oral anticoagulants: quality, usability, readability, and reproducibility compared with FDA-referenced materials.
Oral anticoagulants are frequently associated with preventable hospital admissions, and patient education is essential to their safe and effective use. Patients increasingly use large language models (LLMs) for medication information, yet few studies have compared AI-generated outputs with regulato…
PMID42560425DOI10.1007/s11096-026-02203-2연구 유형기타학술지International journal of clinical pharmacy
https://pubmed.ncbi.nlm.nih.gov/42560425/문헌 04rivaroxabanICSR 검토우선순위 중간
Comparative effectiveness and safety of apixaban vs. rivaroxaban in patients with cirrhosis and portal vein thrombosis.
Portal vein thrombosis (PVT) occurs in ~14% of patients with cirrhosis. Although apixaban and rivaroxaban are increasingly used in this population, comparative data are lacking. We conducted a retrospective cohort study of adults with cirrhosis and PVT initiating apixaban or rivaroxaban. Propensity…
PMID42559699DOI10.1097/MBC.0000000000001446연구 유형기타학술지Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
https://pubmed.ncbi.nlm.nih.gov/42559699/문헌 05rivaroxabanICSR 검토우선순위 중간
Clinical Validation of a Point-of-Care Whole Blood Coagulometer in Patients on Factor Xa Inhibitors.
Currently, no sensitive, widely available, rapid turnaround assays to measure the effect on coagulation of direct oral anticoagulants exist. The point-of-care ClotChek (Perosphere Technologies Inc.) coagulometer was developed to address this unmet need with high sensitivity and precision. This proo…
PMID42556384DOI10.1055/a-2930-1041연구 유형기타학술지Thrombosis and haemostasis
https://pubmed.ncbi.nlm.nih.gov/42556384/문헌 06apixaban근거 검토우선순위 낮음
Significant Left Atrial Appendage Leak After LAA Exclusion System Occluded by ASD Closure Device.
Incomplete left atrial appendage (LAA) closure ("leak") is a challenge of LAA occlusive techniques and carries thromboembolic risk. Closure of significant leaks after surgical AtriClip is rare and less described. An 81-year-old man with atrial fibrillation on apixaban, prior LAA AtriClip (2023), an…
PMID42283686DOI10.1016/j.jaccas.2026.108801연구 유형기타학술지JACC. Case reports
https://pubmed.ncbi.nlm.nih.gov/42283686/문헌 07dabigatranICSR 검토우선순위 중간
Effects of direct oral anticoagulants on cardiac outcomes in atrial fibrillation: a systematic review and network meta-analysis.
Direct oral anticoagulants (DOACs) reduce thromboembolism in atrial fibrillation (AF), but their effect on cardiac outcomes is less studied. Systematic review and network meta-analysis were performed on AF patients on DOACs/vitamin K antagonists (VKAs). Both observational studies and randomized cli…
PMID42547732DOI10.1007/s11739-026-04480-1연구 유형기타학술지Internal and emergency medicine
https://pubmed.ncbi.nlm.nih.gov/42547732/문헌 08warfarinICSR 검토우선순위 중간
Direct Oral Anticoagulants for Atrial Fibrillation in Patients Receiving Hemodialysis: A Review and Discussion of Evidence.
An optimal strategy for managing thrombotic risk in patients with atrial fibrillation (AF) receiving hemodialysis (HD) remains uncertain. To date, the literature has not shown definitive benefit from the use of oral anticoagulants for AF in patients receiving HD. Furthermore, attaining appropriate…
PMID42546121DOI10.1097/CRD.0000000000001417연구 유형기타학술지Cardiology in review
https://pubmed.ncbi.nlm.nih.gov/42546121/문헌 09rivaroxabanICSR 검토우선순위 중간
Antithrombotic strategy according to age in patients with atrial fibrillation and drug-eluting stents: a post hoc analysis of the ADAPT AF-DES randomised trial.
Evidence for non-vitamin K antagonist oral anticoagulant (NOAC) monotherapy for older patients with atrial fibrillation (AF) and drug-eluting stents is lacking. We aimed to evaluate the safety and efficacy of NOAC monotherapy in older AF patients with drug-eluting stents. This is a secondary analys…
PMID42546025DOI10.1093/ageing/afag224연구 유형기타학술지Age and ageing
https://pubmed.ncbi.nlm.nih.gov/42546025/문헌 10rivaroxabanICSR 검토우선순위 중간
Association of Genetic Variants With Rivaroxaban Pharmacokinetics and Pharmacodynamics in Older Patients With Atrial Fibrillation: A Prospective Cohort Study.
Rivaroxaban is frequently used for stroke prevention in atrial fibrillation. Clinicians increasingly encounter complex decision-making regarding oral anticoagulant prescription in older patients with atrial fibrillation. Genetic contributors to variability in rivaroxaban exposure and clinical outco…
PMID42500898DOI10.1161/JAHA.126.049831연구 유형기타학술지Journal of the American Heart Association
https://pubmed.ncbi.nlm.nih.gov/42500898/문헌 11dabigatran근거 검토우선순위 낮음
Decapsulated dabigatran administration via nasogastric tube.
PubMed에 초록이 제공되지 않았습니다.
PMID42045148DOI10.1093/ajhp/zxag125연구 유형기타학술지American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
https://pubmed.ncbi.nlm.nih.gov/42045148/문헌 12dabigatran근거 검토우선순위 낮음
Response to Vijayasimha et al.
PubMed에 초록이 제공되지 않았습니다.
PMID42045147DOI10.1093/ajhp/zxag126연구 유형기타학술지American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
https://pubmed.ncbi.nlm.nih.gov/42045147/문헌 13warfarin근거 검토우선순위 낮음
Day-to-day experiences and challenges of long-term warfarin use among patients with prosthetic heart valves at a National Cardiac Institute in Tanzania: A qualitative study.
Long-term warfarin therapy following prosthetic heart valve placement is essential for preventing valve-related thromboembolic complications. Due to its narrow therapeutic window, maintaining a therapeutic International Normalized Ratio (INR) requires strict adherence to healthcare medication, diet…
PMID42555563DOI10.1371/journal.pone.0355506연구 유형기타학술지PloS one
https://pubmed.ncbi.nlm.nih.gov/42555563/문헌 14warfarinICSR 검토우선순위 중간
Incidence and Predictors of Extracranial Bleeding on Oral Anticoagulants for Stroke Prevention in Patients With Atrial Fibrillation: A COMBINE-AF Analysis.
Extracranial bleeding is the most common complication of oral anticoagulant (OAC) therapy for atrial fibrillation (AF), but its clinical importance for patients may be underrecognized. We sought to characterize extracranial bleeding events according to standardized severity definitions, identify ba…
PMID42549517DOI10.1161/CIRCULATIONAHA.125.079205연구 유형기타학술지Circulation
https://pubmed.ncbi.nlm.nih.gov/42549517/문헌 15warfarinICSR 검토우선순위 중간
Outcomes of Total Knee Arthroplasty in Patients Receiving Chronic Antithrombotic Therapy: A Systematic Review.
With population aging and increasing cardiovascular comorbidity, more patients undergoing total knee arthroplasty (TKA) require chronic antithrombotic therapy. The impact of long-term anticoagulant or antiplatelet use on perioperative and longer-term outcomes after TKA remains unclear. This systema…
PMID42546786DOI10.1016/j.arth.2026.07.047연구 유형기타학술지The Journal of arthroplasty
https://pubmed.ncbi.nlm.nih.gov/42546786/문헌 16warfarinICSR 검토우선순위 중간
Risk prediction of traumatic and non-traumatic subdural hematoma after ischemic stroke: a nationwide competing-risk model with external validation.
Subdural hematoma (SDH) represents a growing hemorrhagic concern among ischemic stroke survivors receiving long-term antithrombotic therapy. Although aging, multimorbidity, and antithrombotic exposure are all contributors to SDH, there is limited evidence on subtype-specific risk factors in stroke…
PMID42545518DOI10.1007/s10143-026-04414-7연구 유형기타학술지Neurosurgical review
https://pubmed.ncbi.nlm.nih.gov/42545518/문헌 17warfarin근거 검토우선순위 낮음
The Effect of Dicloxacillin Administration on Pharmacokinetics of Narrow Therapeutic Window Drugs: Phenytoin and Warfarin.
Dicloxacillin is a penicillinase-resistant beta-lactam antibiotic and potent activator of the Pregnane X receptor (PXR), known to induce CYP2C9, CYP2C19, and CYP3A4 activity. Clinical data suggest it reduces anticoagulation in warfarin-treated patients and increases the risk of thromboembolic event…
PMID42544696DOI10.1002/cpt.70413연구 유형기타학술지Clinical pharmacology and therapeutics
https://pubmed.ncbi.nlm.nih.gov/42544696/문헌 18semaglutide근거 검토우선순위 낮음
AgRP neurons are required for the weight-lowering effects of GLP-1 receptor agonists in female mice.
Glucagon-like peptide-1 receptor agonists (GLP-1RAs), including semaglutide, produce robust and sustained weight loss, yet the central mechanisms supporting their long-term efficacy remain incompletely understood. Agouti-related peptide (AgRP) neurons of the arcuate nucleus are classically activate…
PMID42550908DOI10.1073/pnas.2614476123연구 유형기타학술지Proceedings of the National Academy of Sciences of the United States of America
https://pubmed.ncbi.nlm.nih.gov/42550908/문헌 19semaglutide근거 검토우선순위 낮음
Diagnostic and Management Pitfalls of SGLT2 Inhibitor-Associated Ketoacidosis in the ICU: Lessons Following Cardiac Surgery and GLP-1 Agonist Interaction.
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are cornerstones in the treatment of Type 2 diabetes (T2D), but their use is associated with diabetic ketoacidosis (DKA), a potentially life-threatening complication in the critical care setting. We present two cases of male patients with T2D who d…
PMID42564745DOI10.1155/crcc/4896065연구 유형기타학술지Case reports in critical care
https://pubmed.ncbi.nlm.nih.gov/42564745/문헌 20semaglutideICSR 검토우선순위 중간
Integrating GLP-1 Receptor Agonists Into Dermatology Practice: Safety and Monitoring Strategies.
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have rapidly expanded beyond the treatment of type 2 diabetes mellitus (T2DM) and obesity, with increasing relevance to dermatologic practice as more patients present while receiving these therapies. This medication class now includes oral formul…
PMID42562129DOI10.1016/j.clindermatol.2026.07.030연구 유형기타학술지Clinics in dermatology
https://pubmed.ncbi.nlm.nih.gov/42562129/문헌 21tirzepatideICSR 검토우선순위 중간
Analysis of the efficacy and safety of liraglutide, semaglutide, and tirzepatide for the treatment of overweight and obesity: a systematic review and network meta-analysis.
The rapid rise in overweight and obesity worldwide underscores the need for comparative evidence on long-term pharmacotherapy. The recent introduction of a 7.2 mg maintenance dose of semaglutide warrants particular attention. We assessed the efficacy and safety of glucagon-like peptide-1 (GLP-1) an…
PMID42560457DOI10.1007/s40618-026-03006-y연구 유형기타학술지Journal of endocrinological investigation
https://pubmed.ncbi.nlm.nih.gov/42560457/문헌 22semaglutide근거 검토우선순위 낮음
Correction: Revisional Metabolic and Bariatric Surgery Versus Semaglutide: Which Strategy Has Greater Efficacy for Recurrent Weigh Gain After Primary Bariatric Surgery?
PubMed에 초록이 제공되지 않았습니다.
PMID42560442DOI10.1007/s11695-026-08887-9연구 유형기타학술지Obesity surgery
https://pubmed.ncbi.nlm.nih.gov/42560442/문헌 23semaglutide근거 검토우선순위 낮음
Safety of semaglutide on depressive symptoms among people with HIV in routine clinical care.
Semaglutide, widely used for diabetes and obesity, has raised concerns about neuropsychiatric risks, including depression and suicidality. Given the high burden of depression among people with HIV (PWH), we assessed whether semaglutide initiation worsens depressive symptoms. We conducted a within-p…
PMID42558052DOI10.1097/QAD.0000000000004598연구 유형기타학술지AIDS (London, England)
https://pubmed.ncbi.nlm.nih.gov/42558052/문헌 24semaglutide근거 검토우선순위 낮음
Initiating semaglutide therapy reduces tobacco cigarette smoking intensity among people with HIV.
Smoking remains a major public health issue in people with HIV (PWH). Given the recent uptake of semaglutide for weight management and/or diabetes treatment in PWH and emerging evidence of antiaddictive properties, we studied changes in tobacco cigarette smoking among PWH initiating semaglutide in…
PMID42558050DOI10.1097/QAD.0000000000004596연구 유형기타학술지AIDS (London, England)
https://pubmed.ncbi.nlm.nih.gov/42558050/문헌 25semaglutide근거 검토우선순위 낮음
Endothelial Shear-Stress-Responsive Gene Adenylate Cyclase 4 Suppresses Atherosclerosis by Inhibiting cAMP/PKA-NF-κB Mediated Vascular Inflammation.
Endothelial dysfunction is critical for the pathogenesis of atherosclerosis, particularly in arterial regions exposed to disturbed flow (DF). ADCY4 (adenylate cyclase 4) catalyzes the production of cAMP, a ubiquitous second messenger that regulates cellular and physiological processes. This study i…
PMID42558048DOI10.1161/ATVBAHA.126.324797연구 유형기타학술지Arteriosclerosis, thrombosis, and vascular biology
https://pubmed.ncbi.nlm.nih.gov/42558048/문헌 26semaglutide근거 검토우선순위 낮음
Impact of semaglutide introduction on the use of triptans: an interrupted-time series.
Emerging evidence suggests that glucagon-like peptide-1 receptor agonist (GLP-1RA) may be associated with reduced migraine burden. We aimed to evaluate whether semaglutide for weight management initiation is associated with changes in triptan consumption. We conducted a nationwide interrupted time…
PMID42557547DOI10.1186/s10194-026-02462-4연구 유형기타학술지The journal of headache and pain
https://pubmed.ncbi.nlm.nih.gov/42557547/문헌 27semaglutide근거 검토우선순위 낮음
Efficacy and Hypoglycaemia Outcomes With Once-Weekly IcoSema Versus Comparators in Individuals With Type 2 Diabetes by Kidney and Liver Function: A Post Hoc Analysis of the COMBINE 1-3 Trials.
This post hoc analysis of COMBINE 1-3 assessed efficacy and hypoglycaemia outcomes with IcoSema (once-weekly combination therapy of basal insulin icodec and semaglutide [a glucagon-like peptide-1 analogue]) versus comparators in adults with type 2 diabetes (T2D) by kidney and liver function subgrou…
PMID42557064DOI10.1111/dom.70895연구 유형기타학술지Diabetes, obesity & metabolism
https://pubmed.ncbi.nlm.nih.gov/42557064/문헌 28tirzepatide근거 검토우선순위 낮음
The role of GLP-1 and GIP receptor agonists in the treatment of diabetes and obesity.
Owing to the therapeutic success of glucagon-like peptide-1 receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR) agonists in the management of diabetes and obesity, the pharmacology of these drugs and their receptors has engendered considerable interest. GLP-1 and GIP…
PMID42556625DOI10.1016/j.phrs.2026.108365연구 유형기타학술지Pharmacological research
https://pubmed.ncbi.nlm.nih.gov/42556625/문헌 29semaglutide근거 검토우선순위 낮음
Cup-to-disc ratio in GLP-1 RA Associated Non-Arteritic Anterior Ischemic Optic Neuropathy.
First: to determine whether the cup-to-disc ratio (CDR) of patients with GLP-1 RA associated nonarteritic anterior ischemic optic neuropathy (NAION) is similar to the CDR of NAION patients without GLP-1 RA exposure. Second: to stratify the odds of developing NAION based on CDR. A retrospective, mul…
PMID42556433DOI10.1016/j.ophtha.2026.07.036연구 유형기타학술지Ophthalmology
https://pubmed.ncbi.nlm.nih.gov/42556433/문헌 30semaglutide근거 검토우선순위 낮음
Resmetirom and semaglutide: next-generation therapies for metabolic-associated steatohepatitis. Opportunities, challenges and issues.
Resmetirom and semaglutide are the first drugs to be approved for the pharmacological treatment of metabolic-associated steatohepatitis (MASH) and moderate-to-severe liver fibrosis. However, approval was based on histological endpoints obtained during a relatively short trial period, leaving some i…
PMID42552573DOI10.1080/17446651.2026.2714267연구 유형기타학술지Expert review of endocrinology & metabolism
https://pubmed.ncbi.nlm.nih.gov/42552573/문헌 31tirzepatide근거 검토우선순위 낮음
GLP-1 Receptor Agonist Therapy for Obesity Under Japan's Optimal Use Guideline: A Prospective Real-World Study of Lifestyle Pre-Treatment, Time-Limited Treatment Cap, and Post-Cessation Regain.
Japan's optimal use guideline restricts insurance-reimbursed GLP-1 receptor agonist (GLP-1 RA) therapy for obesity to patients completing a mandatory 6-month lifestyle intervention, caps treatment at 68 weeks (semaglutide 2.4 mg) or 72 weeks (tirzepatide), and mandates subsequent washout. We evalua…
PMID42552238DOI10.1111/dom.71190연구 유형기타학술지Diabetes, obesity & metabolism
https://pubmed.ncbi.nlm.nih.gov/42552238/문헌 32tirzepatideICSR 검토우선순위 중간
Safety and efficacy of glucagon like peptide-1 receptor agonism-based therapies in end-stage renal disease: A systematic review and meta-analysis.
No systematic review and meta-analysis (SRM) has analyzed the safety and efficacy of glucagon like peptide-1 receptor agonism-based therapies (GLP1RA-BT) in people with end stage renal disease (ESRD) [GFR<15ml/min/1.73m 2 or on renal replacement therapy (RRT)]. Hence this SRM analyzed the safety an…
PMID42551699DOI10.1016/j.eprac.2026.07.018연구 유형기타학술지Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
https://pubmed.ncbi.nlm.nih.gov/42551699/문헌 33semaglutide근거 검토우선순위 낮음
In alcohol use disorder and comorbid obesity, weekly semaglutide reduced heavy drinking days at 26 wk.
GIM/FP/GP: [Formula: see text] Public Health: [Formula: see text].
PMID42546302DOI10.7326/ANNALS-26-02636-JC연구 유형기타학술지Annals of internal medicine
https://pubmed.ncbi.nlm.nih.gov/42546302/문헌 34semaglutide근거 검토우선순위 낮음
Trends in GLP-1 Receptor Agonist Prescribing Without Documented Indications.
PubMed에 초록이 제공되지 않았습니다.
PMID42547885DOI10.1111/dom.71153연구 유형기타학술지Diabetes, obesity & metabolism
https://pubmed.ncbi.nlm.nih.gov/42547885/문헌 35tirzepatide근거 검토우선순위 낮음
Peripheral nerve complications from medications utilised for weight loss: a systematic review.
There is a global epidemic of obesity and in this context, the development of novel agents for weight loss has been timely. There have been emerging reports of peripheral nerve complications and this study aimed to systematically review all reported cases associated with medications used for weight…
PMID42547656DOI10.1007/s00415-026-14048-w연구 유형기타학술지Journal of neurology
https://pubmed.ncbi.nlm.nih.gov/42547656/문헌 36semaglutide근거 검토우선순위 낮음
Semaglutide-associated NAION: a proposed 'two-hit' model involving buried optic disc drusen and sustained hypohydration.
Semaglutide-associated non-arteritic anterior ischaemic optic neuropathy (NAION) mechanisms are unclear. We report a 28-year-old man with type 2 diabetes who developed right NAION 4-5 months after starting semaglutide. Multimodal imaging confirmed NAION and bilateral buried optic disc drusen. The a…
PMID42547311DOI10.1136/bjo-2026-329598연구 유형기타학술지The British journal of ophthalmology
https://pubmed.ncbi.nlm.nih.gov/42547311/문헌 37tirzepatideICSR 검토우선순위 중간
GLP-1 receptor agonists in hip, knee and shoulder arthroplasty: Implications for obesity, osteoarthritis, metabolic optimisation and complications.
Glucagon-like peptide-1 receptor agonists and related incretin-based therapies are rapidly changing the management of obesity and metabolic disease. Their increasing use also among patients with osteoarthritis has important implications for hip, knee and shoulder arthroplasty. Beyond weight loss, t…
PMID42546112DOI10.1002/ksa.70557연구 유형기타학술지Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
https://pubmed.ncbi.nlm.nih.gov/42546112/문헌 38tirzepatide근거 검토우선순위 낮음
Real-World Effectiveness and Treatment Patterns of Tirzepatide in a Large UK Digital Health Cohort.
Tirzepatide has demonstrated substantial weight-loss efficacy in clinical trials, but real-world evidence from routine digital prescribing remains limited. We conducted a retrospective cohort study of adults initiating tirzepatide for obesity via a UK digital prescribing service between March 2024…
PMID42560020DOI10.1111/dom.71067연구 유형기타학술지Diabetes, obesity & metabolism
https://pubmed.ncbi.nlm.nih.gov/42560020/문헌 39tirzepatide근거 검토우선순위 낮음
Pharmacotherapy in obstructive sleep apnoea: a clinical guide.
Obstructive Sleep Apnoea (OSA) is a common, yet underdiagnosed disorder, with significant health implications. Continuous positive airway pressure (CPAP) remains the reference standard and first-line therapy. However, successful CPAP usage is influenced by factors such as access, cost, tolerance, p…
PMID42557390DOI10.1007/s11325-026-03724-w연구 유형기타학술지Sleep & breathing = Schlaf & Atmung
https://pubmed.ncbi.nlm.nih.gov/42557390/문헌 40tirzepatide근거 검토우선순위 낮음
Tirzepatide and cardiovascular outcomes.
PubMed에 초록이 제공되지 않았습니다.
PMID42556867DOI10.1136/bmj-2026-100366연구 유형기타학술지BMJ (Clinical research ed.)
https://pubmed.ncbi.nlm.nih.gov/42556867/문헌 41tirzepatideICSR 검토우선순위 중간
Tirzepatide and the risk of atherosclerotic cardiovascular events: population based cohort study.
To estimate the magnitude of reduction in major adverse cardiovascular events (MACE) that would be observed in clinical practice from adding tirzepatide to standard of care treatment. Population based cohort study, using a design, data, and analytical approach previously benchmarked against randomi…
PMID42556854DOI10.1136/bmj-2026-100011연구 유형기타학술지BMJ (Clinical research ed.)
https://pubmed.ncbi.nlm.nih.gov/42556854/문헌 42tirzepatide근거 검토우선순위 낮음
Overweight and obesity induce Toll-like receptor 2-induced Type I IFN signaling.
Toll-like receptor 2 (TLR2) is an innate immune receptor linked to obesity primarily via NF-κB activation. Using a mouse model of overnutrition and in vitro TLR2 stimulation of human peripheral blood mononuclear cells, we show that lipids, advanced glycation end products, and low-density lipoprotei…
PMID42547779DOI10.1038/s44324-026-00125-1연구 유형기타학술지npj metabolic health and disease
https://pubmed.ncbi.nlm.nih.gov/42547779/문헌 43tofacitinib근거 검토우선순위 낮음
Superior Effectiveness of Upadacitinib Over Tofacitinib and Ustekinumab in Bio-Exposed Ulcerative Colitis: The TRIDENT-UC Study.
Despite the progress in advanced therapies (AT) for ulcerative colitis (UC), selecting a second-line treatment after failure remains challenging. Recent guidelines recommend upadacitinib, tofacitinib or ustekinumab as high-efficacy options after prior AT failure. However, real-world comparative dat…
PMID42562116DOI10.1016/j.cgh.2026.07.020연구 유형기타학술지Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
https://pubmed.ncbi.nlm.nih.gov/42562116/문헌 44tofacitinib근거 검토우선순위 낮음
Switching from deuruxolitinib to baricitinib in alopecia areata: a real-world cohort of 36 patients.
PubMed에 초록이 제공되지 않았습니다.
PMID42562095DOI10.1016/j.jaad.2026.08.001연구 유형기타학술지Journal of the American Academy of Dermatology
https://pubmed.ncbi.nlm.nih.gov/42562095/문헌 45tofacitinibICSR 검토우선순위 중간
Tofacitinib for polycaprolactone-induced granuloma: a case report.
PubMed에 초록이 제공되지 않았습니다.
PMID42561836DOI10.1016/j.abd.2026.501441연구 유형기타학술지Anais brasileiros de dermatologia
https://pubmed.ncbi.nlm.nih.gov/42561836/문헌 46tofacitinib근거 검토우선순위 낮음
Utility of mouse precision cut lung slices as an in vitro model for interrogating the lung immune response against bacterial pathogens in the context of immunomodulatory therapeutics.
High rates of respiratory infections have been observed in patients following treatment with immunomodulatory therapeutics, yet preclinical assessment and mechanistic understanding of drug-associated infection risk remains a challenge. Here, an ex vivo infection model of mouse precision-cut lung sl…
PMID42557569DOI10.1186/s12931-026-03856-3연구 유형기타학술지Respiratory research
https://pubmed.ncbi.nlm.nih.gov/42557569/문헌 47tofacitinibICSR 검토우선순위 중간
Exploration and validation of potential diagnostic biomarkers of PANoptosis in periodontitis using bioinformatics approaches.
Periodontitis represents a chronic inflammatory disease resulting from the interaction between plaque-associated microorganisms and the host immune response. PANoptosis, a newly recognized programmed cell death, is linked to multiple inflammatory disorders. However, its role in periodontitis pathog…
PMID42172897DOI10.1016/j.bbrc.2026.153963연구 유형기타학술지Biochemical and biophysical research communications
https://pubmed.ncbi.nlm.nih.gov/42172897/문헌 48tofacitinib근거 검토우선순위 낮음
Development and Validation of Sustainable RP-HPLC Method for Tofacitinib Quantification in MCM-41 and MCM-48 Silica Nanoparticles and its In-vitro Application.
Tofacitinib is a Janus kinase inhibitor approved by the FDA, for the treatment of autoimmune disorders. The research aimed to develop, validate, and apply a simple, rugged, and environmentally sustainable RP-HPLC method for the quantitative estimation of Tofacitinib in in-house developed Mesoporous…
PMID42554830DOI10.1093/jaoacint/qsag073연구 유형기타학술지Journal of AOAC International
https://pubmed.ncbi.nlm.nih.gov/42554830/문헌 49tofacitinibICSR 검토우선순위 중간
Real-World Outcomes and Safety of JAK Inhibitors in Paediatric Alopecia Areata: A Retrospective Multicentre Study.
Alopecia areata (AA) is a non-scarring, immune-mediated hair loss disorder with substantial psychosocial impact in children. Robust paediatric real-world evidence regarding Janus kinase inhibitors (JAKi) for this disease is limited. In this study, we describe real-world clinical outcomes and safety…
PMID42552762DOI10.1111/ajd.70189연구 유형기타학술지The Australasian journal of dermatology
https://pubmed.ncbi.nlm.nih.gov/42552762/문헌 50tofacitinibICSR 검토우선순위 중간
Anti-TNF, Pan-JAK, and JAK1-Selective Inhibition Differentially Alter Mechanisms of Flow-Mediated Dilation in Human Microvessels.
Patients with chronic inflammatory disorders, including inflammatory bowel disease (IBD), carry an increased risk of cardiovascular disease. The 2022 ORAL Surveillance study reported that the pan-selective Janus kinase inhibitor (JAKi) tofacitinib was associated with increased risk of major adverse…
PMID42552281DOI10.1152/ajpheart.00517.2026연구 유형기타학술지American journal of physiology. Heart and circulatory physiology
https://pubmed.ncbi.nlm.nih.gov/42552281/문헌 51tofacitinib근거 검토우선순위 낮음
Age-associated B cells contribute to inflammation via antibody-independent mechanisms in Takayasu's arteritis.
Although Takayasu's arteritis (TAK) is not a prototypical autoantibody-mediated disease, accumulating evidence suggests that B cells are involved. This study aimed to investigate the pathway of B-cell activation and its contributions to TAK pathogenesis. Histological analysis of paravascular lymph…
PMID42549483DOI10.1002/art.70284연구 유형기타학술지Arthritis & rheumatology (Hoboken, N.J.)
https://pubmed.ncbi.nlm.nih.gov/42549483/문헌 52tofacitinibICSR 검토우선순위 중간
JAK inhibitor therapy in CANDLE syndrome: a systematic review of clinical outcomes in 46 patients.
Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome is a rare autosomal recessive autoinflammatory disorder caused by mutations affecting proteasome function. Given the absence of standard therapy, we reviewed the therapeutic potential of Janus kin…
PMID42547647DOI10.1007/s00431-026-07293-8연구 유형기타학술지European journal of pediatrics
https://pubmed.ncbi.nlm.nih.gov/42547647/문헌 53tofacitinib근거 검토우선순위 낮음
Impact of BMI on response to Janus kinase inhibitors in rheumatoid arthritis: an individual patient data meta-analysis of randomised controlled trials.
Obesity is common in patients with rheumatoid arthritis and is associated with poorer disease outcomes. We aimed to evaluate the association between BMI and clinical response to Januse kinase (JAK) inhibitors in patients with rheumatoid arthritis using individual patient data from the JAK inhibitor…
PMID42546722DOI10.1016/S2665-9913(26)00151-7연구 유형기타학술지The Lancet. Rheumatology
https://pubmed.ncbi.nlm.nih.gov/42546722/문헌 54valproate근거 검토우선순위 낮음
Safety and Efficacy of GLP-1 Receptor Agonists in Adults With Epilepsy, Obesity, and Type 2 Diabetes.
Managing obesity in patients with epilepsy is complicated by the weight-gaining properties of essential antiseizure medications (ASMs) such as valproate and pregabalin. We evaluated the safety and efficacy of initiating glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in this population. We co…
PMID42563258DOI10.1002/acn3.70505연구 유형기타학술지Annals of clinical and translational neurology
https://pubmed.ncbi.nlm.nih.gov/42563258/문헌 55valproate근거 검토우선순위 낮음
GLDC, PYCR3, and PID1: Potential biomarkers and therapeutic targets for comorbid breast cancer and depression.
Triple-negative breast cancer (TNBC) and major depressive disorder (MDD) frequently co-occur, yet the shared biological mechanisms underlying this comorbidity remain poorly understood. Increasing evidence suggests that metabolic dysregulation may represent a critical link between tumor progression…
PMID42556581DOI10.1016/j.jad.2026.122352연구 유형기타학술지Journal of affective disorders
https://pubmed.ncbi.nlm.nih.gov/42556581/문헌 56valproateICSR 검토우선순위 중간
A Case of Lamotrigine-Induced Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) With Coagulopathy and Altered Consciousness.
We report a case of severe drug reaction with eosinophilia and systemic symptoms (DRESS) associated with early coagulation abnormalities following lamotrigine administration, in which aggressive treatment, including steroid pulse therapy and plasma exchange, resulted in a favorable outcome. A 20-ye…
PMID42559111DOI10.1002/ams2.70156연구 유형기타학술지Acute medicine & surgery
https://pubmed.ncbi.nlm.nih.gov/42559111/문헌 57valproate근거 검토우선순위 낮음
Salidroside enhances hippocampal neurogenesis in a valproic acid-induced mouse model of autism by suppressing neuroinflammation.
Neuroinflammation plays a pivotal role in the pathogenesis of autism spectrum disorder (ASD) and represents a potential therapeutic target. Salidroside (SLDS), a bioactive compound isolated from Rhodiola rosea L., exhibits potent anti-inflammatory and neuroprotective effects in various neurological…
PMID42551196DOI10.1016/j.intimp.2026.117195연구 유형기타학술지International immunopharmacology
https://pubmed.ncbi.nlm.nih.gov/42551196/문헌 58valproate근거 검토우선순위 낮음
Next-generation precision medicine for mood disorders: reproducible blood biomarkers enable objective diagnostics, subtyping, and targeted therapeutics.
Mood disorders are highly prevalent in society, often disabling, and can lead to a reduced healthspan and lifespan, including by suicide. Depression and bipolar disorders are currently deemed to be chronic and/or treatment-refractory in up to half the patients treated. Additionally, depression and…
PMID42547801DOI10.1038/s41380-026-03736-8연구 유형기타학술지Molecular psychiatry
https://pubmed.ncbi.nlm.nih.gov/42547801/문헌 59valproate근거 검토우선순위 낮음
Baseline neutrophil count, benign ethnic neutropenia risk, and clozapine haematological monitoring: A multi-ethnic retrospective cohort study from the United Arab Emirates.
Concerns about haematological toxicity and absolute neutrophil count (ANC) monitoring may limit clozapine use, particularly in multi-ethnic populations where benign ethnic neutropenia (BEN) and lower baseline ANC are common. We characterised baseline ANC distribution, nationality-derived BEN-risk,…
PMID42546354DOI10.1016/j.schres.2026.07.026연구 유형기타학술지Schizophrenia research
https://pubmed.ncbi.nlm.nih.gov/42546354/문헌 60valproate근거 검토우선순위 낮음
Individual short-chain fatty acids differentially reprogram transcriptional states in colorectal cancer cells.
Short-chain fatty acids (SCFAs) produced by the gut microbiota contribute to intestinal function, immune responses and host metabolism, yet how individual SCFAs shape intracellular gene expression states remains incompletely defined. Here, we used intestinal epithelial-derived colorectal cancer cel…
PMID42223247DOI10.1093/jb/mvag036연구 유형기타학술지Journal of biochemistry
https://pubmed.ncbi.nlm.nih.gov/42223247/