tofacitinib우선순위 낮음근거 검토기타
LITERATURE DETAIL · PMID 42557569
Utility of mouse precision cut lung slices as an in vitro model for interrogating the lung immune response against bacterial pathogens in the context of immunomodulatory therapeutics.
Utility of mouse precision cut lung slices as an in vitro model for interrogating the lung immune response against bacterial pathogens in the context of immunomodulatory therapeutics.
- 저자
- Guanghui Liu, Susann Busch, Taylor S Cohen, Linnea Särén, Johanna Sagemark, Eva Lamm Bergström
- 저널
- Respiratory research
- 공개일
- 2026 Aug 06
- 연구 유형
- 기타
- DOI
- 10.1186/s12931-026-03856-3
문헌 요약
High rates of respiratory infections have been observed in patients following treatment with immunomodulatory therapeutics, yet preclinical assessment and mechanistic understanding of drug-associated infection risk remains a challenge. Here, an ex vivo infection model of mouse precision-cut lung slices (PCLS) is described to address this gap. Naïve mouse…
PV 검토 포인트
누적 안전성 근거로 분류하고 기존 시그널과의 일관성을 확인합니다.