semaglutide우선순위 낮음근거 검토기타
LITERATURE DETAIL · PMID 42558048
Endothelial Shear-Stress-Responsive Gene Adenylate Cyclase 4 Suppresses Atherosclerosis by Inhibiting cAMP/PKA-NF-κB Mediated Vascular Inflammation.
Endothelial Shear-Stress-Responsive Gene Adenylate Cyclase 4 Suppresses Atherosclerosis by Inhibiting cAMP/PKA-NF-κB Mediated Vascular Inflammation.
- 저자
- Wenzhen Bao, Jianfei Xu, Wenjian Nian, Peilin Pang, Wenrun Wu, Zijian Huang
- 저널
- Arteriosclerosis, thrombosis, and vascular biology
- 공개일
- 2026 Aug 06
- 연구 유형
- 기타
- DOI
- 10.1161/ATVBAHA.126.324797
문헌 요약
Endothelial dysfunction is critical for the pathogenesis of atherosclerosis, particularly in arterial regions exposed to disturbed flow (DF). ADCY4 (adenylate cyclase 4) catalyzes the production of cAMP, a ubiquitous second messenger that regulates cellular and physiological processes. This study investigated ADCY4 as a shear-stress-responsive gene in ECs…
PV 검토 포인트
누적 안전성 근거로 분류하고 기존 시그널과의 일관성을 확인합니다.