warfarin우선순위 낮음근거 검토기타
LITERATURE DETAIL · PMID 42544696
The Effect of Dicloxacillin Administration on Pharmacokinetics of Narrow Therapeutic Window Drugs: Phenytoin and Warfarin.
The Effect of Dicloxacillin Administration on Pharmacokinetics of Narrow Therapeutic Window Drugs: Phenytoin and Warfarin.
- 저자
- Chanan Shaul, Waseem Mujahed, Ibrahim Idries, Maor Wanounou, Meir Bialer, Yoseph Caraco
- 저널
- Clinical pharmacology and therapeutics
- 공개일
- 2026 Aug 03
- 연구 유형
- 기타
- DOI
- 10.1002/cpt.70413
문헌 요약
Dicloxacillin is a penicillinase-resistant beta-lactam antibiotic and potent activator of the Pregnane X receptor (PXR), known to induce CYP2C9, CYP2C19, and CYP3A4 activity. Clinical data suggest it reduces anticoagulation in warfarin-treated patients and increases the risk of thromboembolic events. This open-label, sequential drug-drug interaction study…
PV 검토 포인트
누적 안전성 근거로 분류하고 기존 시그널과의 일관성을 확인합니다.