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LITERATURE DETAIL · PMID 42547779
Overweight and obesity induce Toll-like receptor 2-induced Type I IFN signaling.
Overweight and obesity induce Toll-like receptor 2-induced Type I IFN signaling.
- 저자
- Megan Elkins, Amer Al-Musa, Marcos Chiñas, Brian Woods, Aleksandra Bourdine, Lena Ludwig-Radtke
- 저널
- npj metabolic health and disease
- 공개일
- 2026 Aug 03
- 연구 유형
- 기타
- DOI
- 10.1038/s44324-026-00125-1
문헌 요약
Toll-like receptor 2 (TLR2) is an innate immune receptor linked to obesity primarily via NF-κB activation. Using a mouse model of overnutrition and in vitro TLR2 stimulation of human peripheral blood mononuclear cells, we show that lipids, advanced glycation end products, and low-density lipoproteins extend TLR2 signaling beyond NF-κB to promote Type I IF…
PV 검토 포인트
누적 안전성 근거로 분류하고 기존 시그널과의 일관성을 확인합니다.