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LITERATURE DETAIL · PMID 42547647
JAK inhibitor therapy in CANDLE syndrome: a systematic review of clinical outcomes in 46 patients.
JAK inhibitor therapy in CANDLE syndrome: a systematic review of clinical outcomes in 46 patients.
- 저자
- Seyed Mohammad Vahabi, Elnaz Pourgholi, Can Berk Leblebici, William J Crisler, Sama Heidari, Joe K Tung
- 저널
- European journal of pediatrics
- 공개일
- 2026 Aug 04
- 연구 유형
- 기타
- DOI
- 10.1007/s00431-026-07293-8
문헌 요약
Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome is a rare autosomal recessive autoinflammatory disorder caused by mutations affecting proteasome function. Given the absence of standard therapy, we reviewed the therapeutic potential of Janus kinase inhibitors (JAK-Is) in CANDLE syndrome. Following PRIS…
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